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Open Access 01-08-2013 | Original Article

The expression of Toll-like receptors in murine Müller cells, the glial cells in retina

Authors: Xiaomin Lin, Dan Fang, Hongyan Zhou, Shao Bo Su

Published in: Neurological Sciences | Issue 8/2013

Abstract

Müller cells, the principal glial cells of the retina, play an important role in immune responses. Toll-like receptors (TLRs) are members of the pattern recognition receptor family and mediate innate and adaptive immune responses. In this study, we isolated, characterized Müller cells from mouse retina, and analyzed the expression of TLRs in these cells. We found that the mRNA of TLR2, TLR3, TLR4, and TLR5 was highly expressed by Müller cells. PAM3 and LPS, the agonists for TLR2 and TLR4, promoted Müller cells to produce the inflammatory cytokine Interleukine-6 and the chemokine MIP-2/CXCL2. These results suggest that Müller cells may be involved in innate and adaptive responses via TLR signaling in the eye. Our study should facilitate further study of the role of Müller cell in eye diseases and identification of the potential therapeutic targets.

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Title: The expression of Toll-like receptors in murine Müller cells, the glial cells in retina
Authors: Xiaomin Lin
Dan Fang
Hongyan Zhou
Shao Bo Su
Publication date: 01-08-2013
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 8/2013
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-012-1236-1

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The expression of Toll-like receptors in murine Müller cells, the glial cells in retina

Abstract

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Abstract

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