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01-06-2011 | Original Article

Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience

Authors: Marcello Marchetti, Ida Milanesi, Chiara Falcone, Michela De Santis, Luisa Fumagalli, Lorenzo Brait, Livia Bianchi, Laura Fariselli

Published in: Neurological Sciences | Issue 3/2011

Abstract

The treatment of brain metastases is changing. Many different radiotherapy options are now available and under clinical evaluation. As part of this effort, we retrospectively evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in patients with up to three brain metastases. Sixty-five patients with 81 lesions were treated with hypofractionated radiotherapy. Median dose was 24 Gy in three fractions. Median follow-up was 24.6 months. Actuarial tumour control was 75 and 45% at 9 months and 24 months after treatment, respectively. Median survival time was 7.5 months, and 32% of the patients died from brain tumour progression. Actuarial overall survival was 75% at 3 months and 25% at 12 months. Recursive partitioning analysis class was the only significant prognostic factor. Neoadjuvant whole-brain radiotherapy (in 29 patients) had no impact on survival or local control. Neurological status improved in 42 patients (65%). Adverse events were rare and usually mild. This experience suggests HSRT should be considered as an alternative approach in the treatment of one to three metastatic lesions in selected patients.

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Title: Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience
Authors: Marcello Marchetti
Ida Milanesi
Chiara Falcone
Michela De Santis
Luisa Fumagalli
Lorenzo Brait
Livia Bianchi
Laura Fariselli
Publication date: 01-06-2011
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 3/2011
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-010-0473-4

At a glance: The STEP trials

Springer Medicine

Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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