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Published in: Clinical Rheumatology 12/2020

01-12-2020 | Inflammation of the Salivary Gland | Original Article

Diagnostic utility of submandibular and labial salivary gland biopsy in IgG4-related sialadenitis

Authors: Yan-Yan Zhang, Xia Hong, Zhen Wang, Wei Li, Jia-Zeng Su, Yan Chen, Yan Gao, Guang-Yan Yu

Published in: Clinical Rheumatology | Issue 12/2020

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Abstract

Objective

The diagnostic utility of labial salivary gland (LSG) biopsy for IgG4-related sialadenitis remains undetermined. The purpose of the present study was to determine whether submandibular gland biopsy could be replaced by LSG biopsy for diagnosing IgG4-RS.

Patients and methods

Medical records of two groups of patients were reviewed. Group A contained 45 patients suspected to have IgG4-RS who underwent both SMG and LSG biopsies. Group B contained 25 patients who were clinically and pathologically diagnosed with Sjögren syndrome (SS). Biopsy samples were stained using hematoxylin and eosin (HE) and immunohistochemical techniques and observed under an optical microscope. Relevant data describing histopathological characteristics were collected and analyzed.

Results

SMG of IgG4-RS patients presented typical histopathological characteristics of fibrosis and IgG4-positive plasmacytic infiltration, while LSG showed varied characteristics. The sensitivity and accuracy of SMG for diagnosing IgG4-RS were greater than those of LSG (100% and 100% versus 55.3% and 75.7%, respectively, P < 0.05).

Conclusions

Biopsy of SMG showed greater sensitivity and specificity, whereas LSG biopsy showed varied histopathological and immunohistochemical characteristics; thus, SMG biopsy cannot be replaced by LSG biopsy for diagnosis of IgG4-RS.
Key Point
• Biopsy of SMG showed greater sensitivity and specificity than LSG biopsy for diagnosis of IgG4-RS.
Appendix
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Metadata
Title
Diagnostic utility of submandibular and labial salivary gland biopsy in IgG4-related sialadenitis
Authors
Yan-Yan Zhang
Xia Hong
Zhen Wang
Wei Li
Jia-Zeng Su
Yan Chen
Yan Gao
Guang-Yan Yu
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Clinical Rheumatology / Issue 12/2020
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-020-05097-1

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