Skip to main content
Top
Published in: Clinical Rheumatology 12/2017

01-12-2017 | Review Article

Human microbiome, infections, and rheumatic disease

Authors: Ana Clara Caminer, Rebecca Haberman, Jose U. Scher

Published in: Clinical Rheumatology | Issue 12/2017

Login to get access

Abstract

Microbes have coevolved with their human hosts for millions of years and are vital to their normal development and homoeostasis. It is now clear that there is direct and indirect cross talk between the microbiome and host immune responses. However, the exact mechanisms for this microbial influence in disease pathogenesis remain elusive and are now a major research focus.
Literature
1.
go back to reference Yeoh N, Burton JP, Suppiah P, Reid G, Stebbings S (2013) The role of the microbiome in rheumatic diseases. Curr Rheumatol Rep 15(3):314CrossRefPubMed Yeoh N, Burton JP, Suppiah P, Reid G, Stebbings S (2013) The role of the microbiome in rheumatic diseases. Curr Rheumatol Rep 15(3):314CrossRefPubMed
3.
4.
go back to reference Jayatilake JA, Rajapakse S, Weerasingh IE, Wanigasekara P, Vasanthathilaka J (2011) Oral hygiene and periodontal status in a group of patients with rheumatoid arthritis. Indian J Rheumatol 6(3):111–115CrossRef Jayatilake JA, Rajapakse S, Weerasingh IE, Wanigasekara P, Vasanthathilaka J (2011) Oral hygiene and periodontal status in a group of patients with rheumatoid arthritis. Indian J Rheumatol 6(3):111–115CrossRef
5.
go back to reference Detert J, Pischon N, Burmester GR, Buttgereit F (2010) The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 12(5):218CrossRefPubMedPubMedCentral Detert J, Pischon N, Burmester GR, Buttgereit F (2010) The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 12(5):218CrossRefPubMedPubMedCentral
6.
go back to reference Rosenstein ED, Weissmann G, Greenwald RA (2009) Porphyromonas gingivalis, periodontitis and rheumatoid arthritis. Med Hypotheses 73(3):457–458CrossRefPubMed Rosenstein ED, Weissmann G, Greenwald RA (2009) Porphyromonas gingivalis, periodontitis and rheumatoid arthritis. Med Hypotheses 73(3):457–458CrossRefPubMed
7.
go back to reference Payne JB, Golub LM, Thiele GM, Mikuls TR (2015) The link between periodontitis and rheumatoid arthritis: a periodontist’s perspective. Curr Oral Health Rep 2:20–29CrossRefPubMed Payne JB, Golub LM, Thiele GM, Mikuls TR (2015) The link between periodontitis and rheumatoid arthritis: a periodontist’s perspective. Curr Oral Health Rep 2:20–29CrossRefPubMed
8.
go back to reference Dissick A, Redman RS, Jones M, Rangan BV, Reimold A, Griffiths GR, Mikuls TR, Amdur RL, Richards JS, Kerr GS (2010) Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol 81(2):223–230CrossRefPubMed Dissick A, Redman RS, Jones M, Rangan BV, Reimold A, Griffiths GR, Mikuls TR, Amdur RL, Richards JS, Kerr GS (2010) Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol 81(2):223–230CrossRefPubMed
9.
go back to reference Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, Markt J, McGowan D, Kerr GS, Redman RS, Reimold A, Griffiths G, Beatty M, Gonzalez SM, Bergman DA, Hamilton BC, Erickson AR, Sokolove J, Robinson WH, Walker C, Chandad F, O’Dell JR (2014) Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheum 66(5):1090–1100CrossRef Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, Markt J, McGowan D, Kerr GS, Redman RS, Reimold A, Griffiths G, Beatty M, Gonzalez SM, Bergman DA, Hamilton BC, Erickson AR, Sokolove J, Robinson WH, Walker C, Chandad F, O’Dell JR (2014) Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheum 66(5):1090–1100CrossRef
10.
go back to reference Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD (2007) Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 13(3):134–137CrossRefPubMed Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD (2007) Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 13(3):134–137CrossRefPubMed
11.
go back to reference Savioli C, Ribeiro AC, Fabri GM, Calich AL, Carvalho J, Silva CA, Viana VS, Bonfa E, Siqueira JT (2012) Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol 18(4):180–184PubMed Savioli C, Ribeiro AC, Fabri GM, Calich AL, Carvalho J, Silva CA, Viana VS, Bonfa E, Siqueira JT (2012) Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol 18(4):180–184PubMed
12.
go back to reference Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A, Askari A (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80(4):535–540CrossRefPubMedPubMedCentral Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A, Askari A (2009) Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 80(4):535–540CrossRefPubMedPubMedCentral
13.
go back to reference Wegner N, Wait R, Sroka A, Eick S, Nguyen K, Lungberg K, Kinlock A, Culshaw S, Potempa J, Venables PJ (2010) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62(9):2662–2672CrossRefPubMedPubMedCentral Wegner N, Wait R, Sroka A, Eick S, Nguyen K, Lungberg K, Kinlock A, Culshaw S, Potempa J, Venables PJ (2010) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62(9):2662–2672CrossRefPubMedPubMedCentral
14.
go back to reference Routsias JG, Goules JD, Goules A, Charalampakis G, Pikazis D (2011) Autopathogenic correlation of periodontitis and rheumatoid arthritis. Rheumatology (Oxford) 50(7):1189–1193CrossRef Routsias JG, Goules JD, Goules A, Charalampakis G, Pikazis D (2011) Autopathogenic correlation of periodontitis and rheumatoid arthritis. Rheumatology (Oxford) 50(7):1189–1193CrossRef
15.
go back to reference Brusca SB, Abramson SB, Scher JU (2014) Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity. Curr Opin Rheumatol 26(1):101–107CrossRefPubMedPubMedCentral Brusca SB, Abramson SB, Scher JU (2014) Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity. Curr Opin Rheumatol 26(1):101–107CrossRefPubMedPubMedCentral
16.
go back to reference Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O’Dell JR (2009) Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9(1):38–42CrossRefPubMed Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O’Dell JR (2009) Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9(1):38–42CrossRefPubMed
17.
go back to reference Mikuls TR, Theile GM, Deane KD, Payne JB, O’Dell JR, Yu F, Sayles H, Weisman MH, Gregersen PK, Buckner JH, Keating RM, Derber LA, Robinson WH, Holers VM, Norris JM (2012) Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum 64(11):3522–3530CrossRefPubMed Mikuls TR, Theile GM, Deane KD, Payne JB, O’Dell JR, Yu F, Sayles H, Weisman MH, Gregersen PK, Buckner JH, Keating RM, Derber LA, Robinson WH, Holers VM, Norris JM (2012) Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum 64(11):3522–3530CrossRefPubMed
18.
go back to reference Scher JU, Ubeda C, Equinda M, Khanin R, Buischi Y, Viale A, Lipuma L, Attur M, Pillinger MH, Weissmann G, Littman DR, Pamer EG, Bretz WA, Abramson SB (2012) Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 64(10):3083–3094CrossRefPubMedPubMedCentral Scher JU, Ubeda C, Equinda M, Khanin R, Buischi Y, Viale A, Lipuma L, Attur M, Pillinger MH, Weissmann G, Littman DR, Pamer EG, Bretz WA, Abramson SB (2012) Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum 64(10):3083–3094CrossRefPubMedPubMedCentral
19.
go back to reference McLean MH, Dieguez D, Miller LM, Young HA (2015) Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut 64(2):332–341CrossRefPubMed McLean MH, Dieguez D, Miller LM, Young HA (2015) Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut 64(2):332–341CrossRefPubMed
20.
go back to reference de Aquino SG, Adbollahi-Roodsaz S, Koenders MI, van de Loo FA, Pruijn GJ, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar LA, de Molon RS, Avila Campos MJ, Cunha FQ, Cirelli JA, van den Berg WB (2014) Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response. J Immunol 192(9):4103–4111CrossRefPubMed de Aquino SG, Adbollahi-Roodsaz S, Koenders MI, van de Loo FA, Pruijn GJ, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar LA, de Molon RS, Avila Campos MJ, Cunha FQ, Cirelli JA, van den Berg WB (2014) Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response. J Immunol 192(9):4103–4111CrossRefPubMed
21.
go back to reference Karlson EW, Deane K (2012) Environmental and gene-environment interactions and risk of rheumatoid arthritis. Rheum Dis Clin N Am 38(2):405–426CrossRef Karlson EW, Deane K (2012) Environmental and gene-environment interactions and risk of rheumatoid arthritis. Rheum Dis Clin N Am 38(2):405–426CrossRef
22.
go back to reference Catrina AI, Ytterberg AJ, Reynisdottir G, Malmstrom V, Klareskog (2014) Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis. Nat Rev Rheumatol 10(11): 645–653 Catrina AI, Ytterberg AJ, Reynisdottir G, Malmstrom V, Klareskog (2014) Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis. Nat Rev Rheumatol 10(11): 645–653
23.
go back to reference Segal LN, Alekseyenko AV, Clemente JC, Kulkami R, Wu B, Gao Z, Chen H, Berger KI, Goldring RM, Rom WN, Blaser MJ, Weiden MD (2013) Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome 1(1):19CrossRefPubMedPubMedCentral Segal LN, Alekseyenko AV, Clemente JC, Kulkami R, Wu B, Gao Z, Chen H, Berger KI, Goldring RM, Rom WN, Blaser MJ, Weiden MD (2013) Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome 1(1):19CrossRefPubMedPubMedCentral
25.
go back to reference Padyukov L, Silva C, Stolt P, Alfredsson KL (2004) A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 50(10):3085–3092CrossRefPubMed Padyukov L, Silva C, Stolt P, Alfredsson KL (2004) A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 50(10):3085–3092CrossRefPubMed
26.
go back to reference Ytterberg AJ, Joshua V, Reynisdottir G, Tarasova NK, Rutishauser D, Ossipova E, Haj Hensvold A, Eklund A, Skold CM, Grunewald J, Maimstrom V, Jakobsson PJ, Ronnelid J, Padyukov L, Zubarev RA, Klareskog L, Catrina AI (2014) Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation. Ann Rheum Dis 74(9):1772–1777CrossRefPubMed Ytterberg AJ, Joshua V, Reynisdottir G, Tarasova NK, Rutishauser D, Ossipova E, Haj Hensvold A, Eklund A, Skold CM, Grunewald J, Maimstrom V, Jakobsson PJ, Ronnelid J, Padyukov L, Zubarev RA, Klareskog L, Catrina AI (2014) Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation. Ann Rheum Dis 74(9):1772–1777CrossRefPubMed
27.
go back to reference Bhatia SS, Majka DS, Kittelson JM, Parrish LA, Ferucci ED, Deane KD, Arend WP, Rewers M, Holers VM, Norris JM (2007) Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann Rheum Dis 66(2):267–269CrossRefPubMed Bhatia SS, Majka DS, Kittelson JM, Parrish LA, Ferucci ED, Deane KD, Arend WP, Rewers M, Holers VM, Norris JM (2007) Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann Rheum Dis 66(2):267–269CrossRefPubMed
28.
go back to reference Saevarsdottir S, Wedre S, Seddighzadeh M, Bengtsson C, Wesley A, Lindblad S, Askling J, Alfresson L, Klareskog L (2011) Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Register cohorts. Arthritis Rheum 63(1):26–36CrossRefPubMed Saevarsdottir S, Wedre S, Seddighzadeh M, Bengtsson C, Wesley A, Lindblad S, Askling J, Alfresson L, Klareskog L (2011) Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Register cohorts. Arthritis Rheum 63(1):26–36CrossRefPubMed
29.
go back to reference Stolt P, Yahya A, Bengtsson C, Kallberg H, Ronnelid J, Lundberg I, Klareskog L, Alfresson L (2010) Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis 69(6):1072–1076CrossRefPubMed Stolt P, Yahya A, Bengtsson C, Kallberg H, Ronnelid J, Lundberg I, Klareskog L, Alfresson L (2010) Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis 69(6):1072–1076CrossRefPubMed
30.
go back to reference Bengtsson, C, Nordmrk B, Klareskog L, Lundberg I, Alfresson L, The E (2005) Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study. Ann Rheum Dis 64(11): 1588–1594 Bengtsson, C, Nordmrk B, Klareskog L, Lundberg I, Alfresson L, The E (2005) Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study. Ann Rheum Dis 64(11): 1588–1594
31.
go back to reference Webber MP, Moir W, Zeig-Owens R, Glaser MS, Jaber N, Hall C, Berman J, Qayyum B, Loupasakis K, Kelly K, Prezant DJ (2015) Nested case-control study of selected systemic autoimmune diseases in World Trade Center rescue/recovery workers. Arthritis Rheumatol 67(5):1369–1376CrossRefPubMedPubMedCentral Webber MP, Moir W, Zeig-Owens R, Glaser MS, Jaber N, Hall C, Berman J, Qayyum B, Loupasakis K, Kelly K, Prezant DJ (2015) Nested case-control study of selected systemic autoimmune diseases in World Trade Center rescue/recovery workers. Arthritis Rheumatol 67(5):1369–1376CrossRefPubMedPubMedCentral
32.
go back to reference HJ W, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D (2010) Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32(6):815–827CrossRef HJ W, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D (2010) Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32(6):815–827CrossRef
33.
go back to reference Abdollahi-Roodsaz S, Joosten LAB, Koenders MI, Devesa I, Roelofs MF, Radstake TRDJ, Heuvelmans-Jacobs M, Akira S, Nicklin MJH, Ribeiro-Dias F, van den Berd WB (2008) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118(1):205–216CrossRefPubMed Abdollahi-Roodsaz S, Joosten LAB, Koenders MI, Devesa I, Roelofs MF, Radstake TRDJ, Heuvelmans-Jacobs M, Akira S, Nicklin MJH, Ribeiro-Dias F, van den Berd WB (2008) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118(1):205–216CrossRefPubMed
34.
go back to reference Gomez A, Luckey D, Yeoman CJ, Marietta EV, Berg Miller ME, Muray JA, White BA, Taneja V (2012) Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice. PLoS One 7(4):e36095CrossRefPubMedPubMedCentral Gomez A, Luckey D, Yeoman CJ, Marietta EV, Berg Miller ME, Muray JA, White BA, Taneja V (2012) Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice. PLoS One 7(4):e36095CrossRefPubMedPubMedCentral
35.
go back to reference Vaahtovuo J, Munukka E, Korkeamaki M, Luukainen R, Toivanen P (2008) Fecal microbiota in early rheumatoid arthritis. J Rheumatol 35(8):1500–1505PubMed Vaahtovuo J, Munukka E, Korkeamaki M, Luukainen R, Toivanen P (2008) Fecal microbiota in early rheumatoid arthritis. J Rheumatol 35(8):1500–1505PubMed
36.
go back to reference Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolol V, Pamer EG, Abramson SB, Huttenhower C, Littman DR (2013) Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2:e01202CrossRefPubMedPubMedCentral Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolol V, Pamer EG, Abramson SB, Huttenhower C, Littman DR (2013) Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2:e01202CrossRefPubMedPubMedCentral
37.
go back to reference Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Kirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguschi N, Kaymama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K (2016) Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol 68(11):2646–2661CrossRefPubMed Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Kirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguschi N, Kaymama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K (2016) Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol 68(11):2646–2661CrossRefPubMed
38.
39.
go back to reference Mielants H, Veys EM, Cuvelier C, De Vos M, Goemaere S, De Clercq L, Schatteman L, Elewaut D (1995) The evolution of spondyloarthropathies in relation to gut histology. I. Clinical aspects. J Rheumatol 22(12):2266–2272PubMed Mielants H, Veys EM, Cuvelier C, De Vos M, Goemaere S, De Clercq L, Schatteman L, Elewaut D (1995) The evolution of spondyloarthropathies in relation to gut histology. I. Clinical aspects. J Rheumatol 22(12):2266–2272PubMed
40.
go back to reference Manasson J, Scher JU (2015) Spondyloarthritis and the microbiome: new insights from an ancient hypothesis. Curr Rheumatol Rep 17(2):10CrossRefPubMed Manasson J, Scher JU (2015) Spondyloarthritis and the microbiome: new insights from an ancient hypothesis. Curr Rheumatol Rep 17(2):10CrossRefPubMed
42.
go back to reference Smith JA, Colbert RA (2014) Review: the interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol 66(2):231–241CrossRefPubMedPubMedCentral Smith JA, Colbert RA (2014) Review: the interleukin-23/interleukin-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol 66(2):231–241CrossRefPubMedPubMedCentral
43.
44.
go back to reference Kom T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 cells. Annu Rev Immunol 27:485–517CrossRef Kom T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 cells. Annu Rev Immunol 27:485–517CrossRef
45.
go back to reference Manel N, Unutmaz D, Littman DR (2008) The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9(6):641–649CrossRefPubMedPubMedCentral Manel N, Unutmaz D, Littman DR (2008) The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9(6):641–649CrossRefPubMedPubMedCentral
46.
go back to reference Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tiiack C, Pfenning S, Jurgens M, Schmechel S, Konrad A, Goke B, Oschsenkuhn T, Muller-Myhsok B, Lohse P, Brand S (2008) Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn’s disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 14(4):437–445CrossRefPubMed Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tiiack C, Pfenning S, Jurgens M, Schmechel S, Konrad A, Goke B, Oschsenkuhn T, Muller-Myhsok B, Lohse P, Brand S (2008) Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn’s disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 14(4):437–445CrossRefPubMed
47.
go back to reference Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Theil A, Radburch A, Loddenkemper C, Sieper J (2011) Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 13(3):R95CrossRefPubMedPubMedCentral Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Theil A, Radburch A, Loddenkemper C, Sieper J (2011) Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 13(3):R95CrossRefPubMedPubMedCentral
48.
go back to reference Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB (1996) Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 98(4):945–953CrossRefPubMedPubMedCentral Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB (1996) Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 98(4):945–953CrossRefPubMedPubMedCentral
49.
go back to reference Hammer RE, Maika SD, Richardson JA, Tand JP, Taurog JD (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63(5):1099–1112CrossRefPubMed Hammer RE, Maika SD, Richardson JA, Tand JP, Taurog JD (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63(5):1099–1112CrossRefPubMed
50.
go back to reference Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, Akira S, Nakamura T, Sakaguchi S (2005) A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 201(6):949–960CrossRefPubMedPubMedCentral Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, Akira S, Nakamura T, Sakaguchi S (2005) A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 201(6):949–960CrossRefPubMedPubMedCentral
51.
go back to reference Benham H, Rehaume LM, Hasnain SZ, Velasco J, Baillet AC, Tuutu M, Kikly K, Wang R, Tseng HW, Thomas GP, Brown MA, Strutton G, McGuckin MA, Thomas R (2014) Interleukin-23 mediates the intestinal response to microbial beta-1,3-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol 66(7):1755–1767CrossRefPubMed Benham H, Rehaume LM, Hasnain SZ, Velasco J, Baillet AC, Tuutu M, Kikly K, Wang R, Tseng HW, Thomas GP, Brown MA, Strutton G, McGuckin MA, Thomas R (2014) Interleukin-23 mediates the intestinal response to microbial beta-1,3-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol 66(7):1755–1767CrossRefPubMed
52.
go back to reference Rehaume LM, Mondot S, Aguirre de Carcer D, Velasco J, Benham H, Hasnain SZ, Bowman J, Ruutu M, Hansbro PM, McGuckin MA, Morrison M, Thomas R (2014) ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. Arthritis Rheumatol 66(10):2780–2792CrossRefPubMed Rehaume LM, Mondot S, Aguirre de Carcer D, Velasco J, Benham H, Hasnain SZ, Bowman J, Ruutu M, Hansbro PM, McGuckin MA, Morrison M, Thomas R (2014) ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. Arthritis Rheumatol 66(10):2780–2792CrossRefPubMed
53.
go back to reference Gibson GR, Cummings JH, Macfarlane GT (1991) Growth and activities of sulphate-reducing bacteria in gut. FEMS Microbiol Ecol 86:103–112CrossRef Gibson GR, Cummings JH, Macfarlane GT (1991) Growth and activities of sulphate-reducing bacteria in gut. FEMS Microbiol Ecol 86:103–112CrossRef
55.
56.
go back to reference Fahlen A, Engstand L, Baker BS, Powles A, Fry L (2012) Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. Arch Dermatol Res 304(1):15–22CrossRefPubMed Fahlen A, Engstand L, Baker BS, Powles A, Fry L (2012) Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. Arch Dermatol Res 304(1):15–22CrossRefPubMed
57.
go back to reference Scher JU, Ubeda C, Artacho A, Attur M, Isaac M, Reddy SM, Marmon S, Neimann A, Brusca S, Patel T, Manasson J, Pamer EG, Littman DR, Abramson SB (2015) Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol 67(1):128–139CrossRefPubMedPubMedCentral Scher JU, Ubeda C, Artacho A, Attur M, Isaac M, Reddy SM, Marmon S, Neimann A, Brusca S, Patel T, Manasson J, Pamer EG, Littman DR, Abramson SB (2015) Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol 67(1):128–139CrossRefPubMedPubMedCentral
58.
go back to reference Png CW, Linden SK, Gilshenan KS, Zoetendal EG, McSweeney CS, Sly LI, McMuckin MA, Florin TH (2010) Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am J Gastroenterol 105(11):2420–2428CrossRefPubMed Png CW, Linden SK, Gilshenan KS, Zoetendal EG, McSweeney CS, Sly LI, McMuckin MA, Florin TH (2010) Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am J Gastroenterol 105(11):2420–2428CrossRefPubMed
59.
go back to reference Palazzi C, Buskila D, D’Angelo S, D’Amico E, Olivieri I (2012) Autoantibodies in patients with chronic hepatitis C virus infection: pitfalls for the diagnosis of rheumatic diseases. Autoimmun Rev 11(9):659–663CrossRefPubMed Palazzi C, Buskila D, D’Angelo S, D’Amico E, Olivieri I (2012) Autoantibodies in patients with chronic hepatitis C virus infection: pitfalls for the diagnosis of rheumatic diseases. Autoimmun Rev 11(9):659–663CrossRefPubMed
60.
go back to reference Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, ST O, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM (2015) Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis. Arthritis Rheumatol 67(5):1214–1220CrossRefPubMedPubMedCentral Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, ST O, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM (2015) Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis. Arthritis Rheumatol 67(5):1214–1220CrossRefPubMedPubMedCentral
61.
go back to reference Bombardieri M, Alessandri C, Labbadia G, Iannuccelli C, Carlucci F, Riccieri V, Paoletti V, Valesini G (2004) Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement. Arthritis Res Ther 6(2):R137–R141CrossRefPubMedPubMedCentral Bombardieri M, Alessandri C, Labbadia G, Iannuccelli C, Carlucci F, Riccieri V, Paoletti V, Valesini G (2004) Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement. Arthritis Res Ther 6(2):R137–R141CrossRefPubMedPubMedCentral
62.
go back to reference Nikkari S, Luukkainen R, Mottonen T, Meurman O, Hannonen P, Skurnik M, Toivanen P (1994) Does parvovirus B19 have a role in rheumatoid arthritis? Ann Rheum Dis 53(2):106–111CrossRefPubMedPubMedCentral Nikkari S, Luukkainen R, Mottonen T, Meurman O, Hannonen P, Skurnik M, Toivanen P (1994) Does parvovirus B19 have a role in rheumatoid arthritis? Ann Rheum Dis 53(2):106–111CrossRefPubMedPubMedCentral
63.
go back to reference Söderlund M, von Essen R, Haapasaari J, Kiistala U, Kiviluoto O, Hedman K (1997) Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy. Lancet 349(9058):1063–1065CrossRefPubMed Söderlund M, von Essen R, Haapasaari J, Kiistala U, Kiviluoto O, Hedman K (1997) Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy. Lancet 349(9058):1063–1065CrossRefPubMed
64.
go back to reference Page C, Fracois C, Goeb V, Duverlie G (2015) Human parvovirus B19 and autoimmune diseases. Review of the literature and pathophysiological hypotheses. J Clin Virol 72:69–74CrossRefPubMed Page C, Fracois C, Goeb V, Duverlie G (2015) Human parvovirus B19 and autoimmune diseases. Review of the literature and pathophysiological hypotheses. J Clin Virol 72:69–74CrossRefPubMed
65.
go back to reference Becker J, Winthrop KL (2010) Update on rheumatic manifestations of infectious diseases. Curr Opin Rheumatol 22(1):72–77CrossRefPubMed Becker J, Winthrop KL (2010) Update on rheumatic manifestations of infectious diseases. Curr Opin Rheumatol 22(1):72–77CrossRefPubMed
66.
go back to reference Townes JM (2010) Reactive arthritis after enteric infections in the United States: the problem of definition. Clin Infect Dis 50(2):247–254CrossRefPubMed Townes JM (2010) Reactive arthritis after enteric infections in the United States: the problem of definition. Clin Infect Dis 50(2):247–254CrossRefPubMed
67.
68.
go back to reference Stojančević M, Bokic G, Salami HA, Mikov M (2013) The influence of intestinal tract and probiotics on the fate of orally administered drugs. Curr Issues Mol Biol 16(2):55–68PubMed Stojančević M, Bokic G, Salami HA, Mikov M (2013) The influence of intestinal tract and probiotics on the fate of orally administered drugs. Curr Issues Mol Biol 16(2):55–68PubMed
69.
go back to reference Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341(6145):569–573 Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341(6145):569–573
70.
go back to reference Elli M, Colombo O, Tagliabue A (2010) A common core microbiota between obese individuals and their lean relatives? Evaluation of the predisposition to obesity on the basis of the fecal microflora profile. Med Hypotheses 75(4):350–352CrossRefPubMed Elli M, Colombo O, Tagliabue A (2010) A common core microbiota between obese individuals and their lean relatives? Evaluation of the predisposition to obesity on the basis of the fecal microflora profile. Med Hypotheses 75(4):350–352CrossRefPubMed
71.
go back to reference Versini M, Jeandel PY, Rosenthal E, Shoenfeld Y (2014) Obesity in autoimmune diseases: not a passive bystander. Autoimmun Rev 13(9):981–1000CrossRefPubMed Versini M, Jeandel PY, Rosenthal E, Shoenfeld Y (2014) Obesity in autoimmune diseases: not a passive bystander. Autoimmun Rev 13(9):981–1000CrossRefPubMed
72.
go back to reference Rho YH, Solus J, Sokka T, Oeser A, Chung CP, Gebretsadik T, Shintani A, Pincus T, Stein CM (2009) Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis. Arthritis Rheum 60(7):1906–1914CrossRefPubMedPubMedCentral Rho YH, Solus J, Sokka T, Oeser A, Chung CP, Gebretsadik T, Shintani A, Pincus T, Stein CM (2009) Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis. Arthritis Rheum 60(7):1906–1914CrossRefPubMedPubMedCentral
73.
go back to reference Muller H, de Toledo FW, Resch KL (2001) Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scand J Rheumatol 30(1):1–10CrossRefPubMed Muller H, de Toledo FW, Resch KL (2001) Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scand J Rheumatol 30(1):1–10CrossRefPubMed
74.
go back to reference Salazar N, Binetti A, Gueimonde M, Alonso A, Garrido P, Gonzalez del Rey C, Gonzalez C, Ruas-Madiedo P, de los Reyes-Gavilan CG (2011) Safety and intestinal microbiota modulation by the exopolysaccharide-producing strains Bifidobacterium animalis IPLA R1 and Bifidobacterium longum IPLA E44 orally administered to Wistar rats. Int J Food Microbiol 144(3):342–351CrossRefPubMed Salazar N, Binetti A, Gueimonde M, Alonso A, Garrido P, Gonzalez del Rey C, Gonzalez C, Ruas-Madiedo P, de los Reyes-Gavilan CG (2011) Safety and intestinal microbiota modulation by the exopolysaccharide-producing strains Bifidobacterium animalis IPLA R1 and Bifidobacterium longum IPLA E44 orally administered to Wistar rats. Int J Food Microbiol 144(3):342–351CrossRefPubMed
75.
go back to reference Amdekar S, Singh V, Singh R, Sharma P, Keshav P, Kumar A (2011) Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines. J Clin Immunol 31(2):147–154CrossRefPubMed Amdekar S, Singh V, Singh R, Sharma P, Keshav P, Kumar A (2011) Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines. J Clin Immunol 31(2):147–154CrossRefPubMed
76.
go back to reference Jenks K, Stebbings S, Burton J, Schultz M, Herbison P, Highton J (2010) Probiotic therapy for the treatment of spondyloarthritis: a randomized controlled trial. J Rheumatol 37(10):2118–2125CrossRefPubMed Jenks K, Stebbings S, Burton J, Schultz M, Herbison P, Highton J (2010) Probiotic therapy for the treatment of spondyloarthritis: a randomized controlled trial. J Rheumatol 37(10):2118–2125CrossRefPubMed
77.
go back to reference Mandel DR, Eichas K, Holmes J (2010) Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med 10(1):1CrossRefPubMedPubMedCentral Mandel DR, Eichas K, Holmes J (2010) Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med 10(1):1CrossRefPubMedPubMedCentral
78.
go back to reference Allen-Vercoe E, Reid G, Viner N, Glor GB, Hota S, Kim P, Lee C, O’Doherty K, Vanner SJ, Weese JS, Petrof EO (2012) A Canadian Working Group report on fecal microbial therapy: microbial ecosystems therapeutics. Can J Gastroenterol 26(7):457–462CrossRefPubMedPubMedCentral Allen-Vercoe E, Reid G, Viner N, Glor GB, Hota S, Kim P, Lee C, O’Doherty K, Vanner SJ, Weese JS, Petrof EO (2012) A Canadian Working Group report on fecal microbial therapy: microbial ecosystems therapeutics. Can J Gastroenterol 26(7):457–462CrossRefPubMedPubMedCentral
79.
go back to reference Borody TJ, Warren EF, Leis S, Surace R, Ashman O (2003) Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol 37(1):42–47CrossRefPubMed Borody TJ, Warren EF, Leis S, Surace R, Ashman O (2003) Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol 37(1):42–47CrossRefPubMed
80.
go back to reference Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL (2014) Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312(17):1772–1778CrossRefPubMed Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL (2014) Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312(17):1772–1778CrossRefPubMed
Metadata
Title
Human microbiome, infections, and rheumatic disease
Authors
Ana Clara Caminer
Rebecca Haberman
Jose U. Scher
Publication date
01-12-2017
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 12/2017
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-017-3875-3

Other articles of this Issue 12/2017

Clinical Rheumatology 12/2017 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.