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01-12-2015 | Original Article

¹⁸F-FDG PET/CT in patients with adult-onset Still’s disease

Authors: Meng-Jie Dong, Cai-qin Wang, Kui Zhao, Guo-Lin Wang, Mei-Ling Sun, Zhen-Feng Liu, Liqin Xu

Published in: Clinical Rheumatology | Issue 12/2015

Abstract

¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) has become useful for the detection and diagnosis of inflammatory conditions, including rheumatic diseases, immunoglobulin (Ig) G4-related disease and giant cell arteritis. However, few articles based on small sample sizes (n = 7) diagnosed as adult-onset Still’s disease (AOSD) have been published. The study aim was to observe the reliable characteristics and usefulness of ¹⁸F-FDG PET/CT for the evaluation of consecutive patients with AOSD. Eligible patients were selected from among those who had undergone ¹⁸F-FDG PET/CT between May 2007 and June 2014. Twenty-six consecutive AOSD patients were recruited retrospectively according to criteria set by Yamaguchi et al. All patients underwent evaluation by ¹⁸F-FDG PET/CT. The characteristics and usefulness of ¹⁸F-FDG PET/CT for evaluation of consecutive patients with AOSD were evaluated. All 26 patients had ¹⁸F-FDG-avid lesion(s) related to their particular disease. Diffuse and homogeneous accumulation of ¹⁸F-FDG was seen in the bone marrow (26/26; 100 %; maximum standardized uptake (SUV_max), 2.10–6.73) and spleen (25/26; 96.15 %). The SUV_max of affected lymph nodes was 1.3–9.53 (mean ± SD, 4.12 ± 2.24). The SUV_max and size factors (maximum diameter and areas) of affected lymph nodes were significantly different (P = 0.033 and P = 0.012, respectively). ¹⁸F-FDG PET/CT showed the general distribution of ¹⁸F-FDG accumulation. This factor helped to exclude malignant disease and aided the diagnosis of AOSD (42.3 %) in 11 cases when combined with clinical features and aided decisions regarding appropriate biopsy sites, such as the lymph nodes (n = 9) and bone marrow (n = 13). ¹⁸F-FDG PET/CT is a unique imaging method for the assessment of metabolic activity throughout the body in subjects with AOSD. Characteristics or patterns of AOSD observed on ¹⁸F-FDG PET/CT can be used for the indication and diagnosis or to guide the clinical management of ASOD.

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Title: 18F-FDG PET/CT in patients with adult-onset Still’s disease
Authors: Meng-Jie Dong
Cai-qin Wang
Kui Zhao
Guo-Lin Wang
Mei-Ling Sun
Zhen-Feng Liu
Liqin Xu
Publication date: 01-12-2015
Publisher: Springer London
Published in: Clinical Rheumatology / Issue 12/2015
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-015-2901-6

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