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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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Clinical Rheumatology
Published in: Clinical Rheumatology 11/2013

01-11-2013 | Brief Report

Leflunomide, a valid and safe drug for the treatment of chronic anterior uveitis associated with juvenile idiopathic arthritis

Authors: Clara Molina, Consuelo Modesto, Nieves Martín-Begué, Cristina Arnal

Published in: Clinical Rheumatology | Issue 11/2013

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Excerpt

Chronic anterior uveitis (CAU) is an important extra-articular manifestation of juvenile idiopathic arthritis (JIA). …
Literature
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Sabri K, Saurenmann RK, Silverman ED et al (2008) Course, complications, and outcome of juvenile arthritis-related uveitis. J AAPOS 12:539–545PubMedCrossRef
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Dana MR, Merayo-Lloves J, Schaumberg DA et al (1997) Visual outcomes prognosticators in juvenile rheumatoid arthritis-associated uveitis. Ophthalmology 104:236–244PubMedCrossRef
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Silverman E, Mouy R, Spiegel L et al (2005) Leflunomide or methotrexate for juvenile rheumatoid arthritis. N Engl J Med 352:1655–1666PubMedCrossRef
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Petty RE, Southwood TR, Manners P et al (2004) International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision. J Rheumatol 31:390–392PubMed
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Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140:509–516PubMedCrossRef
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Prakash A, Jarvis B (1999) Leflunomide: a review of its use in active rheumatoid arthritis. Drugs 58:1137–1164PubMedCrossRef
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Parikh JG, Tawansy KA, Rao NA (2008) Immunohistochemical study of chronic nongranulomatous anterior uveitis in juvenile idiopathic arthritis. Ophthalmology 115:1833–1836PubMedCrossRef
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Robertson SM, Lang LS (1994) Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. Agents Actions 42:167–172PubMedCrossRef
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Simonini G, Cantarini L, Bresci C et al (2010) Current therapeutic approaches to autoimmune chronic uveitis in children. Autoimmun Rev 9:674–683PubMedCrossRef
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Yu EN, Meniconi ME, Tufail F et al (2005) Outcomes of treatment with immunomodulatory therapy in patients with corticosteroid-resistant juvenile idiopathic arthritis-associated chronic iridocyclitis. Ocul Immunol Inflamm 13:353–360PubMedCrossRef
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Foeldvari I, Wierk A (2005) Methotrexate is an effective treatment for chronic uveitis associated with juvenile idiopathic arthritis. J Rheumatol 32:362–365PubMed
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Heiligenhaus A, Mingels A, Heinz C et al (2007) Methotrexate for uveitis associated with juvenile idiopathic arthritis: value and requirement for additional anti-inflammatory medication. Eur J Ophtalmol 17:743–748
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Tappeiner C, Roesel M, Heinz C et al (2009) Limited value of cyclosporine A for the treatment of patients with uveitis associated with juvenile idiopathic arthritis. Eye (Lond) 23:1192–1198CrossRef
Metadata
Title
Leflunomide, a valid and safe drug for the treatment of chronic anterior uveitis associated with juvenile idiopathic arthritis
Authors
Clara Molina
Consuelo Modesto
Nieves Martín-Begué
Cristina Arnal
Publication date
01-11-2013
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 11/2013
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-013-2315-2

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Developed by: Springer Medicine
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