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01-04-2009 | Original Article

Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction

Authors: Kosuke Ebina, Atsunori Fukuhara, Wataru Ando, Makoto Hirao, Tadashi Koga, Kazuya Oshima, Morihiro Matsuda, Kazuhisa Maeda, Tadashi Nakamura, Takahiro Ochi, Iichiro Shimomura, Hideki Yoshikawa, Jun Hashimoto

Published in: Clinical Rheumatology | Issue 4/2009

Abstract

Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diagnosis of RA and 42 age- and BMI-matched control were enrolled. The severity of RA was evaluated according to the number of destructed joints of overall 68 joints on plain radiographs (37 patients had mild RA and 53 had severe RA). Serum adiponectin level was significantly higher in the severe RA group (17.7 ± 6.7 μg/ml) than in the control (9.1 ± 3.8 μg/ml) and mild RA groups (13.9 ± 6.5 μg/ml) (control vs. mild RA group, P < 0.001; mild RA vs. severe RA group, P < 0.01). These results suggest that increased number of joint destruction is associated with hyperadiponectinemia in established RA patients.

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Title: Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction
Authors: Kosuke Ebina
Atsunori Fukuhara
Wataru Ando
Makoto Hirao
Tadashi Koga
Kazuya Oshima
Morihiro Matsuda
Kazuhisa Maeda
Tadashi Nakamura
Takahiro Ochi
Iichiro Shimomura
Hideki Yoshikawa
Jun Hashimoto
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: Clinical Rheumatology / Issue 4/2009
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-008-1074-y

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