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Published in: Clinical Rheumatology 2/2008

01-12-2008 | Case Report

Post-partum sacral fracture associated with heparin treatment

Authors: Vincent Goëb, Victor Strotz, Mathieu Verdet, Xavier Le Loët, Olivier Vittecoq

Published in: Clinical Rheumatology | Special Issue 2/2008

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Abstract

We report the case of a 19-year-old woman who consulted for low-back pain 3 weeks after her first delivery. This young woman had a personal history of protein C deficiency and was treated daily during her pregnancy with low-molecular-weight heparin. Her body mass index was 34 and she only gained 10 kg during her pregnancy. Since the delivery – which occurred without any complication – she had suffered from a gradually increasing right-buttock pain and limp. Magnetic resonance imaging (MRI) revealed a fracture of the right sacral ala. After analgesia and 1 month of home relative bed rest, the patient recovered her functional capacities. Regarding our patient, who had no potential clinical risk factors for osteoporosis, the causal effect of heparin is thus possible but not certain. This case report illustrates the fact that clinicians should have a high suspicion of pelvic fracture in post-partum women, even in very young ones, presenting sudden onset of low back and pelvic pain, especially when they have received heparin during pregnancy. MRI seems to be the key exam because it is able to detect and stage fractures or microfractures.
Literature
1.
go back to reference McFarland EG, Giangarra C (1996) Sacral stress fractures in athletes. Clin Orthop Relat Res 329:240–243PubMedCrossRef McFarland EG, Giangarra C (1996) Sacral stress fractures in athletes. Clin Orthop Relat Res 329:240–243PubMedCrossRef
2.
go back to reference Klossner D (2000) Sacral stress fracture in a female collegiate distance runner: a case report. J Athl Train 35:453–457PubMed Klossner D (2000) Sacral stress fracture in a female collegiate distance runner: a case report. J Athl Train 35:453–457PubMed
3.
go back to reference Oliveri B, Gomez Acotto C, Mautalen C (1999) Osteomalacia in a patient with severe anorexia nervosa. Rev Rhum Engl Ed 66:505–508PubMed Oliveri B, Gomez Acotto C, Mautalen C (1999) Osteomalacia in a patient with severe anorexia nervosa. Rev Rhum Engl Ed 66:505–508PubMed
4.
go back to reference Chiaruttini M (1987) Transverse sacral fracture with transient neurologic complication. Ann Emerg Med 16:111–113PubMedCrossRef Chiaruttini M (1987) Transverse sacral fracture with transient neurologic complication. Ann Emerg Med 16:111–113PubMedCrossRef
5.
go back to reference Schmid L, Pfirrmann C, Hess T et al (1999) Bilateral fracture of the sacrum associated with pregnancy: a case report. Osteoporos Int 10:91–93PubMedCrossRef Schmid L, Pfirrmann C, Hess T et al (1999) Bilateral fracture of the sacrum associated with pregnancy: a case report. Osteoporos Int 10:91–93PubMedCrossRef
6.
go back to reference Dussa CU, El Daief SG, Sharma SD et al (2005) Atraumatic fracture of the sacrum in pregnancy. J Obstet Gynaecol 25:716–717PubMedCrossRef Dussa CU, El Daief SG, Sharma SD et al (2005) Atraumatic fracture of the sacrum in pregnancy. J Obstet Gynaecol 25:716–717PubMedCrossRef
7.
go back to reference Barbour LA, Kick SD, Steiner JF et al (1994) A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry. Am J Obstet Gynecol 170:862–869PubMed Barbour LA, Kick SD, Steiner JF et al (1994) A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry. Am J Obstet Gynecol 170:862–869PubMed
8.
go back to reference Gouin-Thibault I, Pautas E, Siguret V (2005) Safety profile of different low-molecular weight heparins used at therapeutic dose. Drug Saf 28:333–349PubMedCrossRef Gouin-Thibault I, Pautas E, Siguret V (2005) Safety profile of different low-molecular weight heparins used at therapeutic dose. Drug Saf 28:333–349PubMedCrossRef
9.
go back to reference Sivakumaran M, Ghosh K, Zaidi Y et al (1996) Osteoporosis and vertebral collapse following low-dose, low molecular weight heparin therapy in a young patient. Clin Lab Haematol 18:55–57PubMed Sivakumaran M, Ghosh K, Zaidi Y et al (1996) Osteoporosis and vertebral collapse following low-dose, low molecular weight heparin therapy in a young patient. Clin Lab Haematol 18:55–57PubMed
10.
go back to reference Tsiridis E, Upadhyay N, Giannoudis PV (2006) Sacral insufficiency fractures: current concepts of management. Osteoporos Int 17:1716–1725PubMedCrossRef Tsiridis E, Upadhyay N, Giannoudis PV (2006) Sacral insufficiency fractures: current concepts of management. Osteoporos Int 17:1716–1725PubMedCrossRef
11.
go back to reference Chao EY, Inoue N (2003) Biophysical stimulation of bone fracture repair, regeneration and remodelling. Eur Cell Mater 6:72–84PubMed Chao EY, Inoue N (2003) Biophysical stimulation of bone fracture repair, regeneration and remodelling. Eur Cell Mater 6:72–84PubMed
12.
go back to reference Judge JO, Kleppinger A, Kenny A et al (2005) Home based resistance training improves femoral bone mineral density in women on hormone therapy. Osteoporos Int 16:1096–1108PubMedCrossRef Judge JO, Kleppinger A, Kenny A et al (2005) Home based resistance training improves femoral bone mineral density in women on hormone therapy. Osteoporos Int 16:1096–1108PubMedCrossRef
14.
go back to reference Kanberoglu K, Kantarci F, Cebi D et al (2005) Magnetic resonance imaging in osteomalacic insufficiency fractures of the pelvis. Clin Radiol 60:105–111PubMedCrossRef Kanberoglu K, Kantarci F, Cebi D et al (2005) Magnetic resonance imaging in osteomalacic insufficiency fractures of the pelvis. Clin Radiol 60:105–111PubMedCrossRef
15.
go back to reference Grangier C, Garcia J, Howarth NR et al (1997) Role of MRI in the diagnosis of insufficiency fractures of the sacrum and acetabular roof. Skeletal Radio 26:517–524CrossRef Grangier C, Garcia J, Howarth NR et al (1997) Role of MRI in the diagnosis of insufficiency fractures of the sacrum and acetabular roof. Skeletal Radio 26:517–524CrossRef
Metadata
Title
Post-partum sacral fracture associated with heparin treatment
Authors
Vincent Goëb
Victor Strotz
Mathieu Verdet
Xavier Le Loët
Olivier Vittecoq
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue Special Issue 2/2008
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-008-0898-9

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