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Clinical Rheumatology
Published in: Clinical Rheumatology 1/2007

01-01-2007 | Review

Mast cells in rheumatoid arthritis

Authors: Nicola Maruotti, Enrico Crivellato, Francesco Paolo Cantatore, Angelo Vacca, Domenico Ribatti

Published in: Clinical Rheumatology | Issue 1/2007

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Abstract

Rheumatoid arthritis (RA) is a chronic disease of joints that is characterized by inflammation, abnormal cellular and humoral immune responses, and synovial hyperplasia. Mast cells (MCs) are involved in several of these inflammatory and immune events. MC-derived mediators induce edema, destroy connective tissue, and are involved in lymphocyte chemotaxis and infiltration and in pathological fibrosis of RA joints. Moreover, MCs are involved in angiogenesis during RA, and their proteolytic activity results in cartilage destruction and bone remodeling. Lastly, MCs could be a target in the treatment of RA.
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Metadata
Title
Mast cells in rheumatoid arthritis
Authors
Nicola Maruotti
Enrico Crivellato
Francesco Paolo Cantatore
Angelo Vacca
Domenico Ribatti
Publication date
01-01-2007
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 1/2007
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-006-0305-3

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