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Clinical Rheumatology
Published in: Clinical Rheumatology 5/2007

01-05-2007 | Case Report

Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes

Authors: Yasunobu Takizawa, Hiroko Kanda, Kojiro Sato, Kimito Kawahata, Akihiro Yamaguchi, Hiroshi Uozaki, Jun Shimizu, Shoji Tsuji, Yoshikata Misaki, Kazuhiko Yamamoto

Published in: Clinical Rheumatology | Issue 5/2007

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Abstract

A 58-year-old man concurrently developed polymyositis (PM), interstitial lung disease, and nephrotic-range proteinuria. Renal biopsy revealed focal mesangial proliferative glomerulonephritis (mesPGN) with depositions of immunoglobulin and complements. A combination therapy of corticosteroid, intravenous immunoglobulin, and cyclosporine was found very effective for the patient. Glomerulonephritis associated with PM/dermatomyositis (DM) is rare. In our review of related literature, mesPGN was exclusively observed in polymyositis while membranous nephropathy in DM. The mechanism underlying the association between myositis and glomerulonephritis remains to be elucidated.
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Metadata
Title
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes
Authors
Yasunobu Takizawa
Hiroko Kanda
Kojiro Sato
Kimito Kawahata
Akihiro Yamaguchi
Hiroshi Uozaki
Jun Shimizu
Shoji Tsuji
Yoshikata Misaki
Kazuhiko Yamamoto
Publication date
01-05-2007
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 5/2007
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-006-0200-y

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