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Published in: Journal of Artificial Organs 1/2019

01-03-2019 | Original Article

Interhospital transport of ARDS patients on extracorporeal membrane oxygenation

Authors: Jan Florian Heuer, Moritz Mirschel, Annalen Bleckmann, Michael Quintel, Onnen Moerer

Published in: Journal of Artificial Organs | Issue 1/2019

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Abstract

Veno-venous extracorporeal membrane oxygenation (ECMO) can be a lifesaving therapy for patients with severe acute respiratory distress syndrome (ARDS). ECMO is a technically complex and challenging procedure and should therefore only be performed in specialized centers. Transporting ARDS patients to ECMO centers for treatment can be dangerous because of the risk of hypoxemia during transport. This raises the question if ECMO should not be already initiated in the transferring hospital before transport. Over a 5-year period, we studied ARDS patients who had been transported to our department by our mobile ECMO team for further treatment after ECMO had already been initiated at the referring hospital. Data for analysis were obtained from our patient data management system (PDMS), the referral documents, and from the referring hospitals. Seventy-five patients meeting the selection criteria were studied. All had been successfully cannulated in the transferring hospitals. They were transported to our ECMO center by helicopter (n = 34) or mobile intensive care units (n = 41). No patient died during transport. Forty four of the patients were transported at night. Twenty-six patients (35%) died in our intensive care unit due to a therapy refractory course, comorbidities or limitation of therapy. Patients on ECMO therapy can be safely transferred to a specialist center. Setting up ECMO in an unfamiliar location and the subsequent patient transport can be very challenging and should only be performed by a highly trained, experienced team.
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Literature
1.
go back to reference Ventilation with lower. tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. the acute respiratory distress syndrome network. N Engl J Med. 2000;342:1301–8.CrossRef Ventilation with lower. tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. the acute respiratory distress syndrome network. N Engl J Med. 2000;342:1301–8.CrossRef
2.
go back to reference Guerin C, Reignier J, Richard JC. Prone positioning in the acute respiratory distress syndrome. N Engl J Med. 2013;369:980–1.PubMed Guerin C, Reignier J, Richard JC. Prone positioning in the acute respiratory distress syndrome. N Engl J Med. 2013;369:980–1.PubMed
3.
go back to reference Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372:747–55.CrossRefPubMed Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372:747–55.CrossRefPubMed
4.
go back to reference Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107–16.CrossRefPubMed Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107–16.CrossRefPubMed
5.
go back to reference Forrest P, Ratchford J, Burns B, Herkes R, Jackson A, Plunkett B, et al. Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience. Intensive Care Med. 2011;37:824–30.CrossRefPubMed Forrest P, Ratchford J, Burns B, Herkes R, Jackson A, Plunkett B, et al. Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience. Intensive Care Med. 2011;37:824–30.CrossRefPubMed
6.
go back to reference Lucchini A, De Felippis C, Elli S, Gariboldi R, Vimercati S, Tundo P, et al. Mobile ECMO team for inter-hospital transportation of patients with ARDS: a retrospective case series. Heart Lung Vessels. 2014;6:262–73.PubMed Lucchini A, De Felippis C, Elli S, Gariboldi R, Vimercati S, Tundo P, et al. Mobile ECMO team for inter-hospital transportation of patients with ARDS: a retrospective case series. Heart Lung Vessels. 2014;6:262–73.PubMed
7.
go back to reference Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009;374:1351–63.CrossRefPubMed Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009;374:1351–63.CrossRefPubMed
8.
go back to reference Biscotti M, Agerstrand C, Abrams D, Ginsburg M, Sonett J, Mongero L, et al. One hundred transports on extracorporeal support to an extracorporeal membrane oxygenation center. Ann Thorac Surg. 2015;100:34–9. (discussion 9–40).CrossRefPubMed Biscotti M, Agerstrand C, Abrams D, Ginsburg M, Sonett J, Mongero L, et al. One hundred transports on extracorporeal support to an extracorporeal membrane oxygenation center. Ann Thorac Surg. 2015;100:34–9. (discussion 9–40).CrossRefPubMed
9.
go back to reference Roch A, Hraiech S, Masson E, Grisoli D, Forel JM, Boucekine M, et al. Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center. Intensive Care Med. 2014;40:74–83.CrossRefPubMed Roch A, Hraiech S, Masson E, Grisoli D, Forel JM, Boucekine M, et al. Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center. Intensive Care Med. 2014;40:74–83.CrossRefPubMed
10.
go back to reference Broman LM, Holzgraefe B, Palmer K, Frenckner B. The Stockholm experience: interhospital transports on extracorporeal membrane oxygenation. Crit Care. 2015;19:278.CrossRefPubMedPubMedCentral Broman LM, Holzgraefe B, Palmer K, Frenckner B. The Stockholm experience: interhospital transports on extracorporeal membrane oxygenation. Crit Care. 2015;19:278.CrossRefPubMedPubMedCentral
11.
go back to reference Raspe C, Ruckert F, Metz D, Hofmann B, Neitzel T, Stiller M, et al. Inter-hospital transfer of ECMO-assisted patients with a portable miniaturized ECMO device: 4 years of experience. Perfusion. 2015;30:52–9.CrossRefPubMed Raspe C, Ruckert F, Metz D, Hofmann B, Neitzel T, Stiller M, et al. Inter-hospital transfer of ECMO-assisted patients with a portable miniaturized ECMO device: 4 years of experience. Perfusion. 2015;30:52–9.CrossRefPubMed
13.
go back to reference Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest. 2008;133:1120–7.CrossRefPubMed Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest. 2008;133:1120–7.CrossRefPubMed
14.
go back to reference Costa EL, Slutsky AS, Amato MB. Driving pressure as a key ventilation variable. N Engl J Med. 2015;372:2072.PubMed Costa EL, Slutsky AS, Amato MB. Driving pressure as a key ventilation variable. N Engl J Med. 2015;372:2072.PubMed
15.
go back to reference Parmentier-Decrucq E, Poissy J, Favory R, Nseir S, Onimus T, Guerry MJ, et al. Adverse events during intrahospital transport of critically ill patients: incidence and risk factors. Ann Intensive Care. 2013;3:10.CrossRefPubMedPubMedCentral Parmentier-Decrucq E, Poissy J, Favory R, Nseir S, Onimus T, Guerry MJ, et al. Adverse events during intrahospital transport of critically ill patients: incidence and risk factors. Ann Intensive Care. 2013;3:10.CrossRefPubMedPubMedCentral
16.
go back to reference Ligtenberg JJ, Arnold LG, Stienstra Y, van der Werf TS, Meertens JH, Tulleken JE, et al. Quality of interhospital transport of critically ill patients: a prospective audit. Crit Care. 2005;9:R446-51.CrossRefPubMed Ligtenberg JJ, Arnold LG, Stienstra Y, van der Werf TS, Meertens JH, Tulleken JE, et al. Quality of interhospital transport of critically ill patients: a prospective audit. Crit Care. 2005;9:R446-51.CrossRefPubMed
17.
go back to reference Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564–75.CrossRefPubMed Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354:2564–75.CrossRefPubMed
18.
go back to reference Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Gudermann T, Schulz R, et al. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur Respir J. 2008;32:1639–51.CrossRefPubMed Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Gudermann T, Schulz R, et al. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur Respir J. 2008;32:1639–51.CrossRefPubMed
19.
go back to reference Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: more harm than benefit. Crit Care Med. 2010;38:1348–59.CrossRefPubMed Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: more harm than benefit. Crit Care Med. 2010;38:1348–59.CrossRefPubMed
20.
go back to reference Pappalardo F, Pieri M, Greco T, Patroniti N, Pesenti A, Arcadipane A, et al. Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med. 2013;39:275–81.CrossRefPubMed Pappalardo F, Pieri M, Greco T, Patroniti N, Pesenti A, Arcadipane A, et al. Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med. 2013;39:275–81.CrossRefPubMed
Metadata
Title
Interhospital transport of ARDS patients on extracorporeal membrane oxygenation
Authors
Jan Florian Heuer
Moritz Mirschel
Annalen Bleckmann
Michael Quintel
Onnen Moerer
Publication date
01-03-2019
Publisher
Springer Japan
Published in
Journal of Artificial Organs / Issue 1/2019
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI
https://doi.org/10.1007/s10047-018-1065-y

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