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Hernia
Published in: Hernia 5/2019

01-10-2019 | Growth Factors | Original Article

Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair

Authors: B. East, M. Plencner, M. Otahal, E. Amler, A. C. de Beaux

Published in: Hernia | Issue 5/2019

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Abstract

Purpose

Incisional hernia is the most common complication following abdominal surgery. While mesh repair is common, none of the current meshes mimic the physiology of the abdominal wall. This study compares suture only repair with polypropylene mesh and a prototype of a novel implant (poly-epsilon-caprolactone nanofibers) and their influence on the physiology of an abdominal wall in an animal model.

Methods

27 Chinchilla rabbits were divided into six groups based on the type of the implant. Midline abdominal incision was repaired using one of the compared materials with suture alone serving as the control. 6 weeks post-surgery animals were killed and their explanted abdominal wall subjected to biomechanical testing.

Results

Both—hysteresis and maximum strength curves showed high elasticity and strength in groups where the novel implant was used. Polypropylene mesh proved as stiff and fragile compared to other groups.

Conclusion

Poly-epsilon-caprolactone nanofiber scaffold is able to improve the dynamic properties of healing fascia with no loss of maximum tensile strength when compared to polypropylene mesh in an animal model.
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Metadata
Title
Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair
Authors
B. East
M. Plencner
M. Otahal
E. Amler
A. C. de Beaux
Publication date
01-10-2019
Publisher
Springer Paris
Published in
Hernia / Issue 5/2019
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-019-01940-w

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