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01-06-2008 | Original Article

Analysis of c-myc, PAI-1 and uPAR in patients with incisional hernias

Authors: R. Rosch, M. Binnebösel, K. Junge, P. Lynen-Jansen, P. R. Mertens, U. Klinge, V. Schumpelick

Published in: Hernia | Issue 3/2008

Abstract

Background

Disturbed wound healing leading to alterations in collagen composition has been thought to play a key role in the pathogenesis of incisional hernia formation. The aim of the present study was to further characterise the scarring process in such patients.

Methods

Mature skin scars from patients with either primary or recurrent incisional hernias were compared to mature abdominal skin scars from patients without hernias. The distribution of collagen types I and III was analysed using crosspolarisation microscopy. Expression of c-myc—a parameter for cell differentiation and proliferation—and of PAI-1 and uPAR—parameters of the proteolytic cascade in wound healing—were determined by immunohistochemistry.

Results

In agreement with previous studies, decreased collagen I/III ratios were found in patients with incisional hernias. In these patients, c-myc levels were significantly elevated whereas plasminogen activator inhibitor-1 (PAI-1) and urokinase-plasminogen activator receptor (uPAR) levels were only slightly increased. In contrast to controls, a significant correlation between c-myc, PAI-1 and uPAR expression and collagen I/III ratios was found in patients with incisional hernias.

Conclusion

The differential correlation of collagen types and expression of c-myc, PAI-1 and uPAR within the scar tissue might represent a causal factor in incisional hernia formation.

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Title: Analysis of c-myc, PAI-1 and uPAR in patients with incisional hernias
Authors: R. Rosch
M. Binnebösel
K. Junge
P. Lynen-Jansen
P. R. Mertens
U. Klinge
V. Schumpelick
Publication date: 01-06-2008
Publisher: Springer-Verlag
Published in: Hernia / Issue 3/2008
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI: https://doi.org/10.1007/s10029-007-0311-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Analysis of c-myc, PAI-1 and uPAR in patients with incisional hernias

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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