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01-07-2020 | Glioma | Case Report

A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2

Authors: Ji Hyun Park, Yoon Jin Cha, Jong Hee Chang, Seung-Koo Lee, Se Hoon Kim

Published in: Brain Tumor Pathology | Issue 3/2020

Abstract

We report a rare case of oligodendroglioma with gangliocytic differentiation. A 31-year-old male without a past medical history was admitted with a sudden seizure. On magnetic resonance imaging, an approximately 7-cm mass with necrosis was noted in the right frontal lobe. The patient underwent surgical resection. On microscopy, two morphologically distinct areas with oligodendroglioma- and ganglioglioma-like features were found. Immunohistochemistry showed an absence of CD34 expression, whereas isocitrate dehydrogenase 1 (IDH1) was positive in the glial component. Moreover, IDH1 was positive in the ganglion-like cells as well as in the glial component. Subsequent 1p/19q co-deletion was confirmed by fluorescence in situ hybridization. Finally, a diagnosis of oligodendroglioma with gangliocytic differentiation was made. IDH1/2 molecular test would be basic and essential diagnostic tool in central nervous system tumor of young patients.

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Title: A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2
Authors: Ji Hyun Park
Yoon Jin Cha
Jong Hee Chang
Seung-Koo Lee
Se Hoon Kim
Publication date: 01-07-2020
Publisher: Springer Singapore
Keywords: Glioma
Fluorescence in Situ Hybridization
Glioma
Oligodendroglioma
Glioma
Published in: Brain Tumor Pathology / Issue 3/2020
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-020-00368-w

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A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2

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