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01-06-2020 | Bisphosphonate | Review Article

Laser surgery in management of medication-related osteonecrosis of the jaws: a meta-analysis

Authors: Gustavo Antonio Correa Momesso, Cleidiel Aparecido Araújo Lemos, Joel Ferreira Santiago-Júnior, Leonardo Perez Faverani, Eduardo Piza Pellizzer

Published in: Oral and Maxillofacial Surgery | Issue 2/2020

Abstract

Purpose

The aim of this study was to perform a systematic review and meta-analysis to evaluate the efficacy of laser therapy on medication-related osteonecrosis of the jaw (MRONJ) treatment.

Methods

This study followed PRISMA standards, and an electronic search was performed on the PubMed/MEDLINE, Scopus, and Cochrane databases. Eighty-nine articles were found. After reading the manuscripts, 15 articles remained for the review. Three of them were selected for meta-analysis.

Results

Female gender was predominant (72.5%), and mean age was 66.5 years. Follow-up varied between 3 and 80 months, and the most used bisphosphonate was zoledronic acid (71.6%). Stage II of MRONJ was the most prevalent (68.9%), and the mandible was the most affected site (64.5%). Qualitative data showed that treatment with laser surgery (Er:YAG) was most effective regarding complete healing of the lesion (90%) compared with other treatments. Meta-analysis data showed that low-level laser therapy (LLLT) was more effective than medical treatment (P = 0.006), and surgical treatment was more effective than LLLT (P = 0.008).

Conclusion

Laser surgery was significantly superior to LLLT (p < 0.00001). Therefore, laser surgical therapy seems to be a great management strategy for MRONJ treatment from stage II. LLLT was shown to improve conservative management in earlier MRONJ stages.

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Title: Laser surgery in management of medication-related osteonecrosis of the jaws: a meta-analysis
Authors: Gustavo Antonio Correa Momesso
Cleidiel Aparecido Araújo Lemos
Joel Ferreira Santiago-Júnior
Leonardo Perez Faverani
Eduardo Piza Pellizzer
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Bisphosphonate
Osteonecrosis
Laser
Published in: Oral and Maxillofacial Surgery / Issue 2/2020
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-020-00831-0

At a glance: The STEP trials

Springer Medicine

Laser surgery in management of medication-related osteonecrosis of the jaws: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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