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Oral and Maxillofacial Surgery

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01-06-2012 | Review Article

Oral field cancerization: current evidence and future perspectives

Authors: Punnya V. Angadi, J. K. Savitha, Sanjay S. Rao, Y. Sivaranjini

Published in: Oral and Maxillofacial Surgery | Issue 2/2012

Abstract

Introduction

Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer.

Discussion

This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed.

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Title: Oral field cancerization: current evidence and future perspectives
Authors: Punnya V. Angadi
J. K. Savitha
Sanjay S. Rao
Y. Sivaranjini
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Oral and Maxillofacial Surgery / Issue 2/2012
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-012-0317-x

At a glance: The STEP trials

Springer Medicine

Oral field cancerization: current evidence and future perspectives

Abstract

Introduction

Discussion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Discussion

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