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Medical Molecular Morphology
Published in: Medical Molecular Morphology 2/2020

01-06-2020 | Cataract | Original Paper

Mechanism of atopic cataract caused by eosinophil granule major basic protein

Authors: Naoki Yamamoto, Noriko Hiramatsu, Sumito Isogai, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi

Published in: Medical Molecular Morphology | Issue 2/2020

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Abstract

Atopic cataracts develop under the ages of 40 years, after which visual acuity rapidly declines. However, the mechanism underlying the development of atopic cataracts is not yet clear. We focused on the eosinophil granule major basic protein (MBP), which was detected in the aqueous humor of atopic cataracts previously, and which was cytotoxic. Specifically, we investigated its origin in this fluid and its effects on lens epithelial cells (LECs). MBP immunostaining was positive in atopic cataract-derived LECs, but negative in age-related cataract-derived LECs. MBP mRNA was not detected in either type of cataract, but protein was detected in the aqueous humor. Furthermore, the flare values associated with atopic cataracts were higher than those with age-related cataracts. When MBP was purified from eosinophils or recombinant MBP was added to LEC culture medium, cell viability decreased in a concentration-dependent manner, but an MBP antibody neutralized the cytotoxic effect of this protein towards these cells. These results were consistent with the flow of MBP into the aqueous humor from the blood due to a compromised blood–aqueous barrier. Thus, MBP could further penetrate the lens capsule and adhere to LECs, resulting in decreased cell viability and the development of atopic cataracts.
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Metadata
Title
Mechanism of atopic cataract caused by eosinophil granule major basic protein
Authors
Naoki Yamamoto
Noriko Hiramatsu
Sumito Isogai
Masashi Kondo
Kazuyoshi Imaizumi
Masayuki Horiguchi
Publication date
01-06-2020
Publisher
Springer Singapore
Published in
Medical Molecular Morphology / Issue 2/2020
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-019-00234-5

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