Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Medical Molecular Morphology
Published in: Medical Molecular Morphology 2/2018

01-06-2018 | Review

Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs

Authors: Yoshihito Nakagawa, Yukihiro Akao, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya

Published in: Medical Molecular Morphology | Issue 2/2018

Login to get access

Abstract

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.
Literature
1.
Lee RC, Feinbaum RL. Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854CrossRefPubMed
2.
3.
Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20CrossRefPubMed
4.
5.
6.
Akao Y, Nakagawa Y, Hirata I, Iio A, Itoh T, Kojima K, Nakashima R, Kitade Y, Naoe T (2010) Role of anti-oncomirs miR-143 and -145 in human colorectal tumors. Cancer Gene Ther 17:398–408CrossRefPubMed
7.
Nakagawa Y, Akao Y, Taniguchi K, Kamatani A, Tahara T, Kamano T, Nakano N, Komura N, Ikuno H, Ohmori T, Jodai Y, Miyata M, Nagasaka M, Shibata T, Ohmiya N, Hirata I (2015) Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors. Int J Mol Sci 16:1526–1543CrossRefPubMedPubMedCentral
8.
Akao Y, Noguchi S, Iio A, Kojima K, Takagi T, Naoe T (2011) Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells. Cancer Lett 300:197–204CrossRefPubMed
9.
Tuchiya N, Nakagama H (2010) MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis. Mutat Res 693:94–100CrossRef
10.
Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC (2008) MicroRNA expression profile associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 299:425–436PubMedPubMedCentral
11.
Xiong B, Cheng Y, Ma L, Zhang C (2013) MiR-21 regulates biological behavior through the PTEN/PI-3K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol 42:219–228CrossRefPubMed
12.
Lu Z, Liu M, Stribinskis V, Klinge CM, Ramos KS, Colburn NH, Li Y (2008) MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27:4373–4379CrossRefPubMed
13.
Ahmed FE, Ahmed NC, Vos PW, Bonnerup C, Atkins JN, Casey M, Nuovo GJ, Naziri W, Wiley JE, Mota H, Allison RR (2013) Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle. Cancer Genom Proteom 10:93–113
14.
Zhang N, Li X, Wu CW, Dong Y, Cai M, Mok MT, Wang H, Chen J, Ng SS, Chen M, Sung JJ, Yu J (2013) MicroRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. Oncogene 32:5078–5088CrossRefPubMed
15.
Michael MZ, O’Connor SM, van Holst Pellekaan NG, Young GP, James RJ (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1:882–891PubMed
16.
Minamoto T, Sawaguchi K, Mai M, Yamashita N, Sugimura T, Esumi H (1994) Infrequent K-Ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 54:2841–2844PubMed
17.
Fujimori T, Satonaka K, Yamamura-Idei Y, Nagasako K, Maeda S (1994) Non-involvement of Ras mutations in flat colorectal adenomas and carcinomas. Int J Cancer 57:51–55CrossRefPubMed
18.
Shirai H, Ueno E, Osaki M, Tatebe S, Ito H, Kaibara N (1995) Expression of growth factor and their receptors in human early colorectal carcinomas: immunohistochemical study. Anticancer Res 15:2889–2894PubMed
19.
Sada M, Mitomi H, Igarashi M, Katsumata T, Saigenji K, Okayasu I (1999) Cell kinetics, p53 and Bcl-2 expression, and c-Ki-Ras mutations in flat-elevated tubulovillous adenomas and adenocarcinomas of the colorectum: comparison with polypoid lesions. Scand J Gastroenterol 34:798–807CrossRefPubMed
20.
Kudo S, Kashida H, Nakajima T, Tamura S, Nakajo K (1997) Endoscopic diagnosis and treatment of early colorectal cancer. World J Surg 21:694–701CrossRefPubMed
21.
22.
Uraoka T, Saito Y, Matsuda T, Ikehara H, Gotoda T, Saito D, Fujii T (2006) Endoscopic indication for endoscopic mucosal resection of laterally spreading tumors in the colorectum. Gut 55:1592–1597CrossRefPubMedPubMedCentral
23.
Scarpa M, Castagliuolo I, Castoro C, Pozza A, Scarpa M, Kotsafti A, Angriman I (2014) Inflammatory colonic carcinogenesis: a review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis. World J Gastroenterol 20:6774–6785CrossRefPubMedPubMedCentral
24.
Saraggi D, Fassan M, Mescoli C, Scarpa M, Valeri N, Michielan A, D’Incá R, Rugge M (2016) The molecular landscape of colitis-associated carcinogenesis. Dig Liver Dis 49:326–330CrossRefPubMed
25.
Kobayashi K, Tomita H, Shimizu M, Tanaka T, Suzui N, Miyazaki T, Hara A (2017) p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer. Int J Mol Sci 18:E1284CrossRefPubMed
26.
Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T, Oda Y (2011) Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study. Am J Surg Pathol 35:295–304CrossRefPubMed
27.
Bettington M, Walker N, Rosty C, Brown I, Clouston A, McKeone D, Pearson SA, Leggett B, Whitehall V (2017) Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut 66:97–106CrossRefPubMed
28.
Japanese Society for Cancer of the Colon and Rectum (2013) In Japanese Classification of Colorectal Carcinoma, 8th edn. Kanehara Shuppan, Tokyo
29.
Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T (2007) Down-regulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci 98:1914–1920CrossRefPubMed
30.
Nakagawa Y, Iinuma M, Naoe T, Nozawa Y, Akao Y (2007) Characterized mechanism of α-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Bioorg Med Chem 15:5620–5628CrossRefPubMed
31.
Takagi T, Iio A, Nakagawa Y, Naoe T, Tanigawa N, Akao Y (2009) Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology 77:12–21CrossRefPubMed
32.
33.
Chen Z, Zeng H, Guo Y, Liu P, Pan H, Deng A, Hu J (2010) miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-myc. J Exp Clin Cancer Res 29:151CrossRefPubMedPubMedCentral
34.
English JM, Pearson G, Baer R, Cobb MH (1998) Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. J Biol Chem 73:3854–3860CrossRef
35.
Rothberg PG (1987) The role of the oncogene c-myc in sporadic large bowel cancer and familial polyposis coli. Semin Surg Oncol 3:152–158CrossRefPubMed
36.
Hashimoto K, Nakagawa Y, Morikawa H, Niki M, Egashira Y, Hirata I, Katsu K, Akao Y (2001) Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. Carcinogenesis 22:1965–1970CrossRefPubMed
37.
Akao Y, Kumasaki M, Shinohara H, Sugito N, Kuranaga Y, Tsujino T, Yoshikawa Y, Kitade Y (2018) Impairment of K-Ras signaling networks and increased efficacy of EGFR inhibitors by a novel synthetic miR-143. Cancer Sci (in press)
38.
Su J, Liang H, Yao W, Wang N, Zhang S, Yan X, Feng H, Pang W, Wang Y, Wang X, Fu Z, Liu Y, Zhao C, Zhang J, Zhang CY, Zen K, Chen X, Wang Y (2014) MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer. PLoS One 9:e114420CrossRefPubMedPubMedCentral
39.
Siemens H, Jackstadt R, Kaller M, Hermeking H (2013) Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 4:1399–1415CrossRefPubMedPubMedCentral
40.
Nagano Y, Toiyama Y, Okugawa Y, Imaoka H, Fujikawa H, Yasuda H, Yoshiyama S, Hiro J, Kobayashi M, Ohi M, Araki T, Inoue Y, Mohri Y, Kusunoki M (2016) MicroRNA-7 Is associated with malignant potential and poor prognosis in human colorectal cancer. Anticancer Res 36:6521–6526CrossRefPubMed
41.
Vicinus B, Rubie C, Stegmaier N, Frick VO, Kölsch K, Kauffels A, Ghadjar P, Wagner M, Glanemann M (2013) miR-21 and its target gene CCL20 are both highly overexpressed in the microenvironment of colorectal tumors: significance of their regulation. Oncol Rep 30:1285–1292CrossRefPubMed
42.
Kinzier KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159–170CrossRef
43.
Senda T, Shimomura A, Iizuka-Koga A (2005) Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Anat Sci Int 80:121–131CrossRefPubMed
44.
45.
Muto T, Nagawa H, Watanabe T, Masaki T, Sawada T (1997) Colorectal carcinogenesis: Historical review. Dis Colon Rectum 40:S80–S85CrossRefPubMed
46.
Mukawa K, Fujii S, Takeda J, Kitajima K, Tominaga K, Chibana Y, Fujita M, Ichikawa K, Tomita S, Ono Y, Imura J, Kawamata H, Chiba T, Hiraishi H, Terano A, Fujimori T (2005) Analysis of K-Ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. J Gastroenterol Hepatol 20:1584–1590CrossRefPubMed
47.
Hiraoka S, Kato J, Tatsukawa M, Harada K, Fujita H, Morikawa T, Shiraha H, Shiratori Y (2006) Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-Ras mutations. Gastroenterology 131:379–389CrossRefPubMed
48.
Teixeira CR, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F (1996) Flat-elevated colorectal neoplasms exhibit a high malignant potential. Oncology 53:89–93CrossRefPubMed
49.
Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp VI, Ballegooijen MV, Hankey BF, Shi W, Bond JH, Schapiro M, Joel F, Panish JF, Stewart ET, Waye JD (2012) Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med 366:687–696CrossRefPubMedPubMedCentral
50.
Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R (2008) Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 68:5795–5802CrossRefPubMed
51.
Liao WT, Ye YP, Zhang NJ, Li TT, Wang SY, Cui YM, Qi L, Wu P, Jiao HL, Xie YJ, Zhang C, Wang JX, Ding YQ (2014) MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. J Pathol 232:415–427CrossRefPubMed
52.
Chai J, Wang S, Han D, Dong W, Xie C, Guo H (2015) MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase. Tumour Biol 36:1313–1321CrossRefPubMed
Metadata
Title
Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs
Authors
Yoshihito Nakagawa
Yukihiro Akao
Tomomitsu Tahara
Hiromi Yamashita
Mitsuo Nagasaka
Tomoyuki Shibata
Naoki Ohmiya
Publication date
01-06-2018
Publisher
Springer Japan
Published in
Medical Molecular Morphology / Issue 2/2018
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-018-0186-y

Other articles of this Issue 2/2018

Medical Molecular Morphology 2/2018 Go to the issue

Original Paper

Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues

Original Paper

Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia

Original Paper

SUOX is negatively associated with multistep carcinogenesis and proliferation in oral squamous cell carcinoma

Review

Spatiotemporal coordination of cellular differentiation and tissue morphogenesis in organ of Corti development

Original Paper

H+-ATPase blockade reduced renal gluconeogenesis and plasma glucose in a diabetic rat model

Original Paper

Creatine phosphate disodium salt protects against Dox-induced cardiotoxicity by increasing calumenin