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Medical Molecular Morphology
Published in: Medical Molecular Morphology 2/2018

01-06-2018 | Original Paper

Creatine phosphate disodium salt protects against Dox-induced cardiotoxicity by increasing calumenin

Authors: Yu Wang, Ying Sun, Xin Guo, Yao Fu, Jie Long, Cheng-Xi Wei, Ming Zhao

Published in: Medical Molecular Morphology | Issue 2/2018

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Abstract

Inhibiting endoplasmic reticulum stress (ERS)-induced apoptosis may be a new therapeutic target in cardiovascular diseases. Creatine phosphate disodium salt (CP) has been reported to have cardiovascular protective effect, but its effects on ERS are unknown. The aim of this study was to identify the mechanism by which CP exerts its cardioprotection in doxorubicin (Dox)-induced cardiomyocytes injury. In our study, neonatal rats cardiomyocytes (NRC) was randomly divided into control group, model group, and treatment group. The cell viability and apoptosis were detected. grp78, grp94, and calumenin of the each group were monitored. To investigate the role of calumenin, Dox-induced ERS was compared in control and down-regulated calumenin cardiomyocytes. Our results showed that CP decreased Dox-induced apoptosis and relieved ERS. We found calumenin increased in Dox-induced apoptosis with CP. ERS effector C/EBP homologous protein was down-regulated by CP and it was influenced by calumenin. CP could protect NRC by inhibiting ERS, this mechanisms may be associated with its increasing of calumenin.
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Metadata
Title
Creatine phosphate disodium salt protects against Dox-induced cardiotoxicity by increasing calumenin
Authors
Yu Wang
Ying Sun
Xin Guo
Yao Fu
Jie Long
Cheng-Xi Wei
Ming Zhao
Publication date
01-06-2018
Publisher
Springer Japan
Published in
Medical Molecular Morphology / Issue 2/2018
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-017-0176-5

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