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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 10/2019

01-10-2019 | Intense Pulsed Light | Original Contribution

Abnormal functional network centrality in drug-naïve boys with attention-deficit/hyperactivity disorder

Authors: Ming Zhou, Chuang Yang, Xuan Bu, Yan Liang, Haixi Lin, Xinyu Hu, Hong Chen, Meihao Wang, Xiaoqi Huang

Published in: European Child & Adolescent Psychiatry | Issue 10/2019

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood and is characterized by inattention, impulsivity, and hyperactivity. Observations of distributed functional abnormalities in ADHD suggest aberrant large-scale brain network connectivity. However, few studies have measured the voxel-wise network centrality of boys with ADHD, which captures the functional relationships of a given voxel within the entire connectivity matrix of the brain. Here, to examine the network patterns characterizing children with ADHD, we recruited 47 boys with ADHD and 21 matched control boys who underwent resting-state functional imaging scanning in a 3.0 T MRI unit. We measured voxel-wise network centrality, indexing local functional relationships across the entire brain connectome, termed degree centrality (DC). Then, we chose the brain regions with altered DC as seeds to examine the remote functional connectivity (FC) of brain regions. We found that boys with ADHD exhibited (1) decreased centrality in the left superior temporal gyrus (STG) and increased centrality in the left superior occipital lobe (SOL) and right inferior parietal lobe (IPL); (2) decreased FC between the STG and the putamen and thalamus, which belong to the cognitive cortico-striatal–thalamic–cortical (CSTC) loop, and increased FC between the STG and medial/superior frontal gyrus within the affective CSTC loop; and (3) decreased connectivity between the SOL and cuneus within the dorsal attention network. Our results demonstrated that patients with ADHD show a connectivity-based pathophysiological process in the cognitive and affective CSTC loops and attention network.
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Metadata
Title
Abnormal functional network centrality in drug-naïve boys with attention-deficit/hyperactivity disorder
Authors
Ming Zhou
Chuang Yang
Xuan Bu
Yan Liang
Haixi Lin
Xinyu Hu
Hong Chen
Meihao Wang
Xiaoqi Huang
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 10/2019
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-019-01297-6

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