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Open Access 01-09-2009 | Original Contribution

Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? The TRAILS study

Authors: Rianne Marsman, Judith G. M. Rosmalen, Albertine J. Oldehinkel, Johan Ormel, Jan K. Buitelaar

Published in: European Child & Adolescent Psychiatry | Issue 9/2009

Abstract

To examine whether HPA-axis activity mediates the relationship between obstetric complications (OCs) and externalizing behavior problems, and to investigate whether this model is different for boys and girls. In a population-based cohort of 1,768 10- to 12-year-old early adolescents, we assessed the cortisol awakening response and evening cortisol levels. Externalizing behavior problems were assessed using the Child Behavior Checklist and the Youth Self-Report. OCs were retrospectively assessed in a parent interview. OCs significantly predicted externalizing behavior problems, but OCs did not predict HPA-axis activity. Thus, the mediation model was not supported. In addition to the relationship between HPA-axis activity and externalizing behavior problems, which is specific for girls, there is also a relationship between OCs and externalizing behavior problems. However, these two mechanisms are not related to each other indicating that HPA-axis activity is not a mediator in the relationship between OCs and externalizing behavior problems. Future research should focus on understanding the mechanism through which OCs cause externalizing behavior problems.

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Title: Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? The TRAILS study
Authors: Rianne Marsman
Judith G. M. Rosmalen
Albertine J. Oldehinkel
Johan Ormel
Jan K. Buitelaar
Publication date: 01-09-2009
Publisher: D. Steinkopff-Verlag
Published in: European Child & Adolescent Psychiatry / Issue 9/2009
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-009-0014-y

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Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? The TRAILS study

Abstract

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Abstract

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