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Clinical Oral Investigations

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01-08-2020 | Laser | Original Article

Demineralization detection in orthodontics using an ophthalmic optical coherence tomography device equipped with a multicolor fluorescence module

Authors: Sinan Şen, Ralf Erber, Nadine Deurer, Gül Orhan, Christopher J. Lux, Sebastian Zingler

Published in: Clinical Oral Investigations | Issue 8/2020

Abstract

Objectives

Demineralizations such as white spot lesions are among the most prevalent side effects during orthodontic treatment. Fluorescence devices, including quantitative light-induced fluorescence (QLF), exploiting the intrinsic fluorescence of enamel and teeth and most recently optical coherence tomography (OCT) were introduced for early demineralization detection. In addition to near-infrared OCT scanning, multicolor modules allow for imaging with different laser wavelengths and the detection of reflective- and fluorescent light. The aim of this study was to evaluate a modified multicolor ophthalmic OCT device for the detection of early carious lesions in vitro and in vivo.

Materials and methods

Twenty-seven extracted lesion free human teeth were randomly assigned to three different demineralization protocols. Carious lesion detection was performed using macrophotography, OCT, and reflectance/fluorescence imaging using green laser and blue laser light. In addition, teeth of 5 orthodontic patients were OCT scanned, and fluorescence imaging using blue laser light was performed to assess demineralization after orthodontic therapy.

Results

Both in vitro and in vivo, OCT allowed for precise determination of lesion depth and enamel loss. Fluorescence imaging using blue laser light was most sensitive for the detection of early demineralization in vitro and in vivo. However, established and severe demineralizations were also reliably detected by macrophotography in vitro and in vivo.

Conclusion

Demineralization can be detected with high sensitivity using blue fluorescence imaging with multicolor OCT devices.

Clinical relevance

In the future, OCT fluorescence imaging might be considered for longitudinal monitoring of dental hard tissue during orthodontic treatment in clinical trials.

Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A (2015) Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: a meta-analysis. J Int Soc Prev Community Dent 5(6):433–439. https://doi.org/10.4103/2231-0762.167719 CrossRefPubMedPubMedCentral

Jiang H, Tai BJ, Du MQ (2015) Patterns and risk factors for white spot lesions in orthodontic patients with fixed appliances. Chin J Dent Res 18(3):177–183PubMed

Bock NC, Seibold L, Heumann C, Gnandt E, Roder M, Ruf S (2017) Changes in white spot lesions following post-orthodontic weekly application of 1.25 per cent fluoride gel over 6 months-a randomized placebo-controlled clinical trial. Part II: clinical data evaluation. Eur J Orthod 39(2):144–152. https://doi.org/10.1093/ejo/cjw061 CrossRefPubMed

Enaia M, Bock N, Ruf S (2011) White-spot lesions during multibracket appliance treatment: a challenge for clinical excellence. Am J Orthod Dentofacial Orthop 140(1):e17–e24. https://doi.org/10.1016/j.ajodo.2010.12.016 CrossRefPubMed

Hochli D, Hersberger-Zurfluh M, Papageorgiou SN, Eliades T (2017) Interventions for orthodontically induced white spot lesions: a systematic review and meta-analysis. Eur J Orthod 39(2):122–133. https://doi.org/10.1093/ejo/cjw065 CrossRefPubMed

Benson PE, Parkin N, Dyer F, Millett DT, Furness S, Germain P (2013) Fluorides for the prevention of early tooth decay (demineralised white lesions) during fixed brace treatment. Cochrane Database Syst Rev 12:CD003809. https://doi.org/10.1002/14651858.CD003809.pub3 CrossRef

Kirschneck C, Christl JJ, Reicheneder C, Proff P (2016) Efficacy of fluoride varnish for preventing white spot lesions and gingivitis during orthodontic treatment with fixed appliances-a prospective randomized controlled trial. Clin Oral Investig 20(9):2371–2378. https://doi.org/10.1007/s00784-016-1730-6 CrossRefPubMed

Stecksen-Blicks C, Renfors G, Oscarson ND, Bergstrand F, Twetman S (2007) Caries-preventive effectiveness of a fluoride varnish: a randomized controlled trial in adolescents with fixed orthodontic appliances. Caries Res 41(6):455–459. https://doi.org/10.1159/000107932 CrossRefPubMed

Arends J, ten Bosch JJ (1992) Demineralization and remineralization evaluation techniques. J Dent Res 71:924–928CrossRef

10.

Benson PE, Higham SM, Pender N (2003) An in vitro assessment using transverse microradiography of the effect on mineral loss of etching enamel for in situ studies. Orthod Craniofac Res 6(4):242–249CrossRef

11.

Damen JJ, Exterkate RA, ten Cate JM (1997) Reproducibility of TMR for the determination of longitudinal mineral changes in dental hard tissues. Adv Dent Res 11(4):415–419. https://doi.org/10.1177/08959374970110040601 CrossRefPubMed

12.

Silva PF, de Holanda Ferreira DA, Meira KR, Forte FD, Chaves AM, de Sousa FB (2014) Dentin reactions to caries are misinterpreted by histological "gold standards". F1000Res 3:13. doi:https://doi.org/10.12688/f1000research.3-13.v1

13.

Ten Bosch JJ, Angmar-Mansson B (1991) A review of quantitative methods for studies of mineral content of intra-oral caries lesions. J Dent Res 70(1):2–14. https://doi.org/10.1177/00220345910700010301 CrossRefPubMed

14.

Campos SAG, Vieira MLO, de Sousa FB (2017) Correlation between ICDAS and histology: differences between stereomicroscopy and microradiography with contrast solution as histological techniques. PLoS One 12(8):e0183432. https://doi.org/10.1371/journal.pone.0183432 CrossRefPubMedPubMedCentral

15.

Heinrich-Weltzien R, Kühnisch J, van der Veen M, de Josselin de Jong E, Stösser L (2003) Quantitative light-induced fluorescence (QLF)--a potential method for the dental practitioner. Quintessence Int 34(3):181–188PubMed

16.

Kuhnisch J, Heinrich-Weltzien R (2004) Quantitative light-induced fluorescence (QLF)--a literature review. Int J Comput Dent 7(4):325–338PubMed

17.

Knosel M, Bojes M, Jung K, Ziebolz D (2012) Increased susceptibility for white spot lesions by surplus orthodontic etching exceeding bracket base area. J Orofac Orthop 141(5):574–582. https://doi.org/10.1016/j.ajodo.2011.11.017 CrossRef

18.

Ko HY, Kang SM, Kim HE, Kwon HK, Kim BI (2015) Validation of quantitative light-induced fluorescence-digital (QLF-D) for the detection of approximal caries in vitro. J Dent 43(5):568–575. https://doi.org/10.1016/j.jdent.2015.02.010 CrossRefPubMed

19.

Tatano R, Ehrlich EE, Berkels B, Sirazitdinova E, Deserno TM, Fritz UB (2017) Quantitative light-induced fluorescence images and digital photographs- reproducibility of manually marked demineralisations. J Orofac Orthop 78(2):137–143. https://doi.org/10.1007/s00056-016-0069-6 CrossRefPubMed

20.

Colston B, Sathyam U, Dasilva L, Everett M, Stroeve P, Otis L (1998) Dental OCT. Opt Express 3(6):230–238CrossRef

21.

Colston BW Jr, Everett MJ, Da Silva LB, Otis LL, Stroeve P, Nathel H (1998) Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography. Appl Opt 37(16):3582–3585CrossRef

22.

Wang XJ, Milner TE, de Boer JF, Zhang Y, Pashley DH, Nelson JS (1999) Characterization of dentin and enamel by use of optical coherence tomography. Appl Opt 38(10):2092–2096CrossRef

23.

Louie T, Lee C, Hsu D, Hirasuna K, Manesh S, Staninec M, Darling CL, Fried D (2010) Clinical assessment of early tooth demineralization using polarization sensitive optical coherence tomography. Lasers Surg Med 42(10):738–745. https://doi.org/10.1002/lsm.21013 CrossRefPubMedPubMedCentral

24.

Chan KH, Tom H, Lee RC, Kang H, Simon JC, Staninec M, Darling CL, Pelzner RB, Fried D (2016) Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention. Lasers Surg Med 48(10):915–923. https://doi.org/10.1002/lsm.22500 CrossRefPubMedPubMedCentral

25.

Nee A, Chan K, Kang H, Staninec M, Darling CL, Fried D (2014) Longitudinal monitoring of demineralization peripheral to orthodontic brackets using cross polarization optical coherence tomography. J Dent 42(5):547–555. https://doi.org/10.1016/j.jdent.2014.02.011 CrossRefPubMedPubMedCentral

26.

Machoy M, Seeliger J, Szyszka-Sommerfeld L, Koprowski R, Gedrange T, Wozniak K (2017) The use of optical coherence tomography in dental diagnostics: a state-of-the-art review. J Healthc Eng 2017:7560645. https://doi.org/10.1155/2017/7560645 CrossRefPubMedPubMedCentral

27.

Amaechi BT, Podoleanu A, Higham SM, Jackson DA (2003) Correlation of quantitative light-induced fluorescence and optical coherence tomography applied for detection and quantification of early dental caries. J Biomed Opt 8(4):642–647. https://doi.org/10.1117/1.1606685 CrossRefPubMed

28.

Turkistani A, Nakashima S, Shimada Y, Tagami J, Sadr A (2015) Microgaps and demineralization Progress around composite restorations. J Dent Res 94(8):1070–1077. https://doi.org/10.1177/0022034515589713 CrossRefPubMed

29.

Maia AM, de Freitas AZ, de Campello LS, Gomes AS, Karlsson L (2016) Evaluation of dental enamel caries assessment using quantitative light induced fluorescence and optical coherence tomography. J Biophotonics 9(6):596–602. https://doi.org/10.1002/jbio.201500111 CrossRefPubMed

30.

Espigares J, Sadr A, Hamba H, Shimada Y, Otsuki M, Tagami J, Sumi Y (2015) Assessment of natural enamel lesions with optical coherence tomography in comparison with microfocus x-ray computed tomography. J Med Imaging (Bellingham) 2(1):014001. https://doi.org/10.1117/1.JMI.2.1.014001 CrossRef

31.

Golde J, Tetschke F, Walther J, Rosenauer T, Hempel F, Hannig C, Koch E, Kirsten L (2018) Detection of carious lesions utilizing depolarization imaging by polarization sensitive optical coherence tomography. J Biomed Opt 23(7):1–8. https://doi.org/10.1117/1.JBO.23.7.071203 CrossRefPubMed

32.

Borisova E, Uzunov T, Avramov L (2006) Laser-induced autofluorescence study of caries model in vitro. Lasers Med Sci 21(1):34–41. https://doi.org/10.1007/s10103-005-0365-7 CrossRefPubMed

33.

van der Veen MH, ten Bosch JJ (1995) Autofluorescence of bulk sound and in vitro demineralized human root dentin. Eur J Oral Sci 103(6):375–381CrossRef

34.

Johnson NW (1966) Differences in the shape of human enamel crystallites after partial destruction by caries, EDTA and various acids. Arch Oral Biol 11(12):1421–1424CrossRef

35.

Tabatabaei N, Mandelis A, Amaechi BT (2011) Thermophotonic lock-in imaging of early demineralized and carious lesions in human teeth. J Biomed Opt 16(7):071402. https://doi.org/10.1117/1.3564890 CrossRefPubMed

36.

Yu OY, Zhao IS, Mei ML, Lo EC-M, Chu C-H (2017) A review of the common models used in mechanistic studies on demineralization-remineralization for Cariology research. Dentistry Journal 5(2):20CrossRef

37.

Sen S, Erber R, Kunzmann K, Kirschner S, Weyer V, Schilling L, Brockmann MA, Rues S, Orhan G, Lux CJ, Zingler S (2018) Assessing abrasion of orthodontic surface sealants using a modified ophthalmic optical coherence tomography device. Clin Oral Investig. https://doi.org/10.1007/s00784-018-2410-5

38.

Alsayed EZ, Hariri I, Sadr A, Nakashima S, Bakhsh TA, Shimada Y, Sumi Y, Tagami J (2015) Optical coherence tomography for evaluation of enamel and protective coatings. Dent Mater J 34(1):98–107. https://doi.org/10.4012/dmj.2014-215 CrossRefPubMed

39.

Meng Z, Yao XS, Yao H, Liang Y, Liu T, Li Y, Wang G, Lan S (2009) Measurement of the refractive index of human teeth by optical coherence tomography. J Biomed Opt 14(3):034010. https://doi.org/10.1117/1.3130322 CrossRefPubMed

40.

Tezuka H, Shimada Y, Matin K, Ikeda M, Sadr A, Sumi Y, Tagami J (2016) Assessment of cervical demineralization induced by Streptococcus mutans using swept-source optical coherence tomography. J Med Imaging (Bellingham) 3(1):014504. https://doi.org/10.1117/1.JMI.3.1.014504 CrossRef

41.

Ten Cate JM (2012) Novel anticaries and remineralizing agents: prospects for the future. J Dent Res 91(9):813–815. https://doi.org/10.1177/0022034512455032 CrossRefPubMed

42.

Aden A, Anthony A, Brigi C, Merchant MS, Siraj H, Tomlins PH (2017) Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography. J Biomed Opt 22(7):76020. https://doi.org/10.1117/1.JBO.22.7.076020 CrossRefPubMed

43.

Gimenez T, Piovesan C, Braga MM, Raggio DP, Deery C, Ricketts DN, Ekstrand KR, Mendes FM (2015) Visual inspection for caries detection: a systematic review and meta-analysis. J Dent Res 94(7):895–904. https://doi.org/10.1177/0022034515586763 CrossRefPubMed

44.

Alfano RR, Yao SS (1981) Human teeth with and without dental caries studied by visible luminescent spectroscopy. J Dent Res 60(2):120–122. https://doi.org/10.1177/00220345810600020401 CrossRefPubMed

45.

Pretty IA (2006) Caries detection and diagnosis: novel technologies. J Dent 34(10):727–739. https://doi.org/10.1016/j.jdent.2006.06.001 CrossRefPubMed

46.

Jones RS, Fried D (2006) Remineralization of enamel caries can decrease optical reflectivity. J Dent Res 85(9):804–808. https://doi.org/10.1177/154405910608500905 CrossRefPubMedPubMedCentral

47.

Lee YK (2015) Fluorescence properties of human teeth and dental calculus for clinical applications. J Biomed Opt 20(4):040901. https://doi.org/10.1117/1.JBO.20.4.040901 CrossRefPubMed

48.

Schwendicke F, Stolpe M, Meyer-Lueckel H, Paris S (2015) Detecting and treating occlusal caries lesions: a cost-effectiveness analysis. J Dent Res 94(2):272–280. https://doi.org/10.1177/0022034514561260 CrossRefPubMedPubMedCentral

49.

Stahl J, Kang H, Fried D (2010) Imaging simulated secondary caries lesions with cross polarization OCT. Proc SPIE Int Soc Opt Eng 7549:754905PubMedPubMedCentral

50.

Lammeier C, Li Y, Lunos S, Fok A, Rudney J, Jones RS (2012) Influence of dental resin material composition on cross-polarization-optical coherence tomography imaging. J Biomed Opt 17(10):106002. https://doi.org/10.1117/1.JBO.17.10.106002 CrossRefPubMedPubMedCentral

51.

Lenton P, Rudney J, Chen R, Fok A, Aparicio C, Jones RS (2012) Imaging in vivo secondary caries and ex vivo dental biofilms using cross-polarization optical coherence tomography. Dental materials : official publication of the Academy of Dental Materials 28(7):792–800. https://doi.org/10.1016/j.dental.2012.04.004 CrossRef

52.

Holtzman JS, Osann K, Pharar J, Lee K, Ahn YC, Tucker T, Sabet S, Chen Z, Gukasyan R, Wilder-Smith P (2010) Ability of optical coherence tomography to detect caries beneath commonly used dental sealants. Lasers Surg Med 42(8):752–759. https://doi.org/10.1002/lsm.20963 CrossRefPubMedPubMedCentral

53.

Walther J, Schnabel C, Tetschke F, Rosenauer T, Golde J, Ebert N, Baumann M, Hannig C, Koch E (2018) In vivo imaging in the oral cavity by endoscopic optical coherence tomography. J Biomed Opt 23(7):1–13. https://doi.org/10.1117/1.JBO.23.7.071207 CrossRefPubMed

Title: Demineralization detection in orthodontics using an ophthalmic optical coherence tomography device equipped with a multicolor fluorescence module
Authors: Sinan Şen
Ralf Erber
Nadine Deurer
Gül Orhan
Christopher J. Lux
Sebastian Zingler
Publication date: 01-08-2020
Publisher: Springer Berlin Heidelberg
Keyword: Laser
Published in: Clinical Oral Investigations / Issue 8/2020
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-03116-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Demineralization detection in orthodontics using an ophthalmic optical coherence tomography device equipped with a multicolor fluorescence module

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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