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01-05-2019 | CO2 Laser | Review

Treatment of actinic cheilitis: a systematic review

Authors: Arthur Pias Salgueiro, Luciano Henrique de Jesus, Isadora Follak de Souza, Pantelis Varvaki Rados, Fernanda Visioli

Published in: Clinical Oral Investigations | Issue 5/2019

Abstract

Objectives

Actinic cheilitis is a potentially malignant disorder caused by excessive sun exposure. It affects the lower lip of individuals, mostly those with light skin color. Different treatments have been proposed for AC; however, no consensus has been reached on the best option available.

Materials and methods

The present study describes the results of a computer-based systematic search conducted on electronic databases to identify the best therapies.

Results

A total of 29 journal articles were selected, and the results were divided according to the type of treatment employed: laser therapy, chemotherapy agents, surgical treatment, and application of anti-inflammatory agents. Clinically, photodynamic therapy showed positive results, with improvement in up to 100% of the patients; however, histopathological improvement varied greatly, from 16 to 100%. Among the chemotherapeutic agents assessed, imiquimod showed the best results: clinical improvement in 80 to 100% of the patients, and histopathological improvement in 73 to 100%. Regarding studies describing surgical approaches, the main focus was the search for the best technique, rather than the cure of AC. Finally, studies employing anti-inflammatory agents are sparse and have small samples, thus providing limited results.

Conclusion

The scientific evidence available on the treatment of AC is scarce and heterogeneous, photodynamic therapy, and imiquimod application are promising.

Clinical relevance

The study of the treatments for AC in the form of a systematic review allows us to evaluate the results against the different treatments. Being a potentially malignant lesion, it is important to seek evidence about the best results found.

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Title: Treatment of actinic cheilitis: a systematic review
Authors: Arthur Pias Salgueiro
Luciano Henrique de Jesus
Isadora Follak de Souza
Pantelis Varvaki Rados
Fernanda Visioli
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: CO2 Laser
Photodynamic Therapy
Chemical Peel
Erythema
Laser
Published in: Clinical Oral Investigations / Issue 5/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-02895-z

ACC 2024 Congress

Springer Medicine

Treatment of actinic cheilitis: a systematic review

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

ACC 2024 Congress

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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