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Clinical Oral Investigations
Published in: Clinical Oral Investigations 12/2019

01-12-2019 | Chronic Myeloid Leukemia | Original Article

Association of oral mucosa hyperpigmentation with imatinib mesylate use: a cross-sectional study and a systematic literature review

Authors: Sicília Rezende Oliveira, Luciana Gravito de Azevedo Branco, Amanda Leal Rocha, Denise Vieira Travassos, Gustavo Henrique Romani Magalhães, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Lucas Guimarães Abreu, Tarcília Aparecida da Silva

Published in: Clinical Oral Investigations | Issue 12/2019

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Abstract

Objectives

To assess the association between oral mucosa hyperpigmentation in patients with leukemia and imatinib mesylate use. Additionally, we compared our data to those obtained from a systematic review.

Materials and methods

A cross-sectional study was conducted with 74 patients undergoing treatment with imatinib mesylate. Sociodemographic characteristics, oral mucosa alterations, and medical history were evaluated. Oral hyperpigmentation was scored. The use of imatinib mesylate and hydroxyurea was evaluated. Association between oral hyperpigmentation and imatinib mesylate was assessed. A systematic review was also conducted to retrieve case reports or case series of patients with oral hyperpigmentation associated with imatinib mesylate.

Results

Among the 74 participants, 41 were male (55.4%) and 33 were female (44.6%). Participants’ mean age was 49.3 years. Sixty-six (89.2%) patients developed hyperpigmented lesions in the hard palate mucosa. In multivariate analysis, patients who had used imatinib mesylate for > 72 months had a hyperpigmentation score 1.62 times higher than those who had used this medication during a shorter period. Patients who had used hydroxyurea for > 30 days had a hyperpigmentation score 1.43 times higher than those who had used this medication during a shorter period. The systematic review retrieved 20 clinical cases of patients undergoing imatinib mesylate treatment and exhibiting oral hyperpigmentation.

Conclusions

The development of oral hyperpigmentation is associated with imatinib mesylate use. Hydroxyurea seems to increment such an association.

Clinical relevance

To assist providers in the differential diagnosis of hyperpigmented lesions associated with imatinib mesylate, as well as in the clinical management of such lesions.
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Metadata
Title
Association of oral mucosa hyperpigmentation with imatinib mesylate use: a cross-sectional study and a systematic literature review
Authors
Sicília Rezende Oliveira
Luciana Gravito de Azevedo Branco
Amanda Leal Rocha
Denise Vieira Travassos
Gustavo Henrique Romani Magalhães
Felipe Paiva Fonseca
Ricardo Alves Mesquita
Lucas Guimarães Abreu
Tarcília Aparecida da Silva
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 12/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-019-02886-0

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