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Clinical Oral Investigations
Published in: Clinical Oral Investigations 10/2019

01-10-2019 | Oral Cancer | Original Article

A novel histopathological scoring system for patients with oral squamous cell carcinoma

Authors: Ali-Farid Safi, Kathrin Grochau, Uta Drebber, Volker Schick, Oliver Thiele, Tim Backhaus, Hans-Joachim Nickenig, Joachim E. Zöller, Matthias Kreppel

Published in: Clinical Oral Investigations | Issue 10/2019

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Abstract

Objectives

Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters.

Materials and methods

Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points.

Results

T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate.

Conclusion

Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins.

Clinical relevance

Our presented histoscore improves prediction of the overall survival of patients with OSCC.
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Metadata
Title
A novel histopathological scoring system for patients with oral squamous cell carcinoma
Authors
Ali-Farid Safi
Kathrin Grochau
Uta Drebber
Volker Schick
Oliver Thiele
Tim Backhaus
Hans-Joachim Nickenig
Joachim E. Zöller
Matthias Kreppel
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 10/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-019-02804-4

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