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Clinical Oral Investigations

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01-09-2019 | Original Article

Association of somatosensory dysfunction with symptom duration in burning mouth syndrome

Authors: Kosuke Watanabe, Noboru Noma, Naohiko Sekine, Daiki Takanezawa, Chisa Hirota, Eli Eliav, Yoshiki Imamura

Published in: Clinical Oral Investigations | Issue 9/2019

Abstract

Objectives

A standardized battery of quantitative sensory tests developed by the German Research Network on Neuropathic Pain (DFNS) was used to assess the association between somatosensory dysfunction and disease duration in patients with burning mouth syndrome (BMS).

Materials and methods

The 28 female participants with BMS were classified according to disease duration: ≤ 6 months (subchronic BMS, n = 15) and > 6 months (chronic BMS, n = 13); 29 age- and sex-matched healthy volunteers (control group) were recruited from staff of a dental hospital. The DFNS quantitative sensory testing protocol was applied at the ulnar surface of the right forearm and the tip of the tongue. Values for BMS patients and controls were compared and analyzed.

Results

The mechanical detection threshold (MDT) was significantly higher (i.e., loss of sensation) at the tongue tip in the chronic BMS group than in the control group (p = 0.011), whereas mechanical pain sensitivity (MPS) at the forearm was significantly higher (i.e., gain of sensation) in the chronic BMS group than in the control group (Z score = − 2.13 and 1.99, respectively). Multivariate analyses revealed that BMS patients could be discriminated from controls by using pressure pain threshold at the tongue (79.3%) (in the subchronic BMS group) and by MDT and MPS at the tongue tip and MPS at the forearm (96.6 and 89.7%, respectively) (in the chronic BMS group).

Conclusions

In BMS patients with long disease duration, MDT showed loss of sensation.

Clinical relevance

Increased MPS suggests that a neuropathic mechanism in the peripheral and central nervous systems is involved in BMS development.

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Title: Association of somatosensory dysfunction with symptom duration in burning mouth syndrome
Authors: Kosuke Watanabe
Noboru Noma
Naohiko Sekine
Daiki Takanezawa
Chisa Hirota
Eli Eliav
Yoshiki Imamura
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 9/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2765-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Association of somatosensory dysfunction with symptom duration in burning mouth syndrome

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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