Top

Published in:

01-03-2019 | Original Article

Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren’s syndrome: a pilot study

Authors: Asta Tvarijonaviciute, Carmen Zamora, Silvia Martinez-Subiela, Fernando Tecles, Francisca Pina, Pia Lopez-Jornet

Published in: Clinical Oral Investigations | Issue 3/2019

Abstract

Objectives

To evaluate salivary adiponectin and adenosine deaminase (ADA) in women suffering from Sjögren’s syndrome (SS).

Methods

Salivary adiponectin and ADA were measured in patients with SS (n = 17) and compared to their values in healthy controls (n = 13) and patients suffering from drug-induced xerostomia (non-SS sicca group; n = 19). A clinical history was made for each patient, patients were examined clinically, and xerostomia inventory (XI) was performed.

Results

Salivary adiponectin corrected by total protein was higher in patients with SS than in healthy individuals (P < 0.05) or patients with non-SS sicca (P < 0.01) and correlated with XI (r = 0.555; P < 0.05). Salivary ADA was higher in patients with SS and non-SS sicca compared to controls (P < 0.05 in both cases).

Conclusion

The results of the present study indicate that adiponectin and ADA are increased in the saliva of patients with SS.

Clinical relevance

Salivary adiponectin corrected by total protein can be a potential biomarker of SS.

Trial registration

NCT03156569

Guggenheimer J, Moore PA (2003) Xerostomia: etiology, recognition and treatment. J Am Dent Assoc 134:61–69. https://doi.org/10.14219/JADA.ARCHIVE.2003.0018 CrossRefPubMed

Villa A, Wolff A, Narayana N et al (2016) World workshop on oral medicine VI: a systematic review of medication-induced salivary gland dysfunction. Oral Dis 22:365–382. https://doi.org/10.1111/odi.12402 CrossRefPubMed

Ergun S, Çekici A, Topcuoglu N et al (2010) Oral status and Candida colonization in patients with Sjögren’s syndrome. Med Oral Patol Oral Cir Bucal Mar 11515:310–315. https://doi.org/10.4317/medoral.15.e310 CrossRef

Manoussakis MN, Moutsopoulos HM (2000) Sjögren’s syndrome: autoimmune epithelitis. Best Pract Res Clin Rheumatol 14:73–95. https://doi.org/10.1053/BERH.1999.0078 CrossRef

Fox RI (2005) Sjögren’s syndrome. Lancet (London, England) 366:321–331. https://doi.org/10.1016/S0140-6736(05)66990-5 CrossRef

Delaleu N, Jonsson MV, Appel S, Jonsson R (2008) New concepts in the pathogenesis of Sjögren’s syndrome. Rheum Dis Clin N Am 34:833–845, vii. https://doi.org/10.1016/j.rdc.2008.08.004 CrossRef

Katsiougiannis S, Wong DTW (2016) The proteomics of saliva in Sjögren’s syndrome. Rheum Dis Clin N Am 42:449–456. https://doi.org/10.1016/j.rdc.2016.03.004 CrossRef

Rhodus N, Dahmer L, Lindemann K et al (1998) s-IgA and cytokine levels in whole saliva of Sjögren’s syndrome patients before and after oral pilocarpine hydrochloride administration: a pilot study. Clin Oral Investig 2:191–196. https://doi.org/10.1007/s007840050069 CrossRefPubMed

Kang EH, Lee YJ, Hyon JY et al (2011) Salivary cytokine profiles in primary Sjögren’s syndrome differ from those in non-Sjögren sicca in terms of TNF-α levels and Th-1/Th-2 ratios. Clin Exp Rheumatol 29:970–976PubMed

10.

Katsiougiannis S, Kapsogeorgou EK, Manoussakis MN, Skopouli FN (2006) Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin. Arthritis Rheum 54:2295–2299. https://doi.org/10.1002/art.21944 CrossRefPubMed

11.

De Sanctis JB, Zabaleta M, Bianco NE et al (2009) Serum adipokine levels in patients with systemic lupus erythematosus. Autoimmunity 42:272–274. https://doi.org/10.1080/08916930902828031 CrossRefPubMed

12.

Zamani B, Jamali R, Jamali A (2012) Serum adenosine deaminase may predict disease activity in rheumatoid arthritis. Rheumatol Int 32:1967–1975. https://doi.org/10.1007/s00296-011-1912-0 CrossRefPubMed

13.

Salesi M, Ghazvini RA, Farajzadegan Z et al (2012) Serum adenosine deaminase in patients with rheumatoid arthritis treated with methotrexate. J Res Pharm Pract 1:72–76. https://doi.org/10.4103/2279-042X.108374 CrossRefPubMedPubMedCentral

14.

Saghiri R, Ghashghai N, Movaseghi S et al (2012) Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern. Rheumatol Int 32:1633–1638. https://doi.org/10.1007/s00296-011-1836-8 CrossRefPubMed

15.

Torgutalp M, Efe C, Babaoglu H, Kav T (2017) Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis. World J Gastroenterol 23:3876–3882. https://doi.org/10.3748/wjg.v23.i21.3876 CrossRefPubMedPubMedCentral

16.

Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26:439–451. https://doi.org/10.1210/er.2005-0005 CrossRefPubMed

17.

Su Y-C, Xiang R-L, Zhang Y et al (2013) Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non-obese diabetic mice. Oral Dis 20:n/a. https://doi.org/10.1111/odi.12197 CrossRef

18.

Iizuka H, Koizumi H, Kamigaki K et al (1981) Two forms of adenosine deaminase in pig epidermis. J Dermatol 8:91–95. https://doi.org/10.1111/j.1346-8138.1981.tb02573.x CrossRefPubMed

19.

MacDermott RP, Tritsch GL, Formeister JF (1980) Adenosine deaminase and nucleoside phosphorylase activities in normal human blood mononuclear cell subpopulations. Clin Exp Immunol 42:303–307PubMedPubMedCentral

20.

Sullivan JL, Osborne WRA, Wedgwood RJ (1977) Adenosine deaminase activity in lymphocytes. Br J Haematol 37:157–158. https://doi.org/10.1111/j.1365-2141.1977.tb08825.x CrossRefPubMed

21.

Rai B, Kaur J, Jacobs R, Anand SC (2011) Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue. Clin Oral Investig 15:347–349. https://doi.org/10.1007/s00784-010-0404-z CrossRefPubMed

22.

Saracoglu U, Guven O, Durak I (2005) Adenosine deaminase and 5′-nucleotidase activities in saliva from patients with oral and laryngeal cancer. Oral Dis 11:323–325. https://doi.org/10.1111/j.1601-0825.2005.01131.x CrossRefPubMed

23.

Vitali C, Bombardieri S, Jonsson R et al (2002) Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558. https://doi.org/10.1136/ARD.61.6.554 CrossRefPubMedPubMedCentral

24.

Löe H (1967) The gingival index, the plaque index and the retention index systems. J Periodontol 38:610–616. https://doi.org/10.1902/jop.1967.38.6_part2.610 CrossRef

25.

Thomson WM (2007) Measuring change in dry-mouth symptoms over time using the xerostomia inventory. Gerodontology 24:30–35. https://doi.org/10.1111/j.1741-2358.2007.00137.x CrossRefPubMed

26.

Tvarijonaviciute A, Aznar-Cayuela C, Rubio CP et al (2017) Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. J Oral Pathol Med 46:387–392. https://doi.org/10.1111/jop.12522 CrossRefPubMed

27.

Tvarijonaviciute A, Castillo C, Ceron JJ et al (2017) Leptin and NGF in saliva of patients with diabetes mellitus type 2: a pilot study. J Oral Pathol Med 46:853–855. https://doi.org/10.1111/jop.12587 CrossRefPubMed

28.

Lopez-Jornet P, Cayuela CA, Tvarijonaviciute A et al (2016) Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin. J Oral Pathol Med 45:211–217. https://doi.org/10.1111/jop.12345 CrossRefPubMed

29.

Delacour H, Bousquet A, Fontan E, Ceppa F (2013) Ammonia does not interfere with the Diazyme adenosine deaminase test. Clin Chem Lab Med 51:e225–e226. https://doi.org/10.1515/cclm-2013-0115 CrossRefPubMed

30.

Toussirot E, Gaugler B, Bouhaddi M et al (2010) Elevated adiponectin serum levels in women with systemic autoimmune diseases. Mediat Inflamm 2010(938408):–6. https://doi.org/10.1155/2010/938408

31.

Augusto KL, Bonfa E, Pereira RMR et al (2016) Metabolic syndrome in Sjögren’s syndrome patients: a relevant concern for clinical monitoring. Clin Rheumatol 35:639–647. https://doi.org/10.1007/s10067-015-3072-1 CrossRefPubMed

32.

Contreras-Aguilar MD, Escribano D, Martínez-Subiela S et al (2017) Influence of the way of reporting alpha-amylase values in saliva in different naturalistic situations: a pilot study. PLoS One 12:e0180100. https://doi.org/10.1371/journal.pone.0180100 CrossRefPubMedPubMedCentral

33.

Barranco T, Tvarijonaviciute A, Tecles F, et al. (2017) Changes in CK, LDH and AST in saliva samples after an intense exercise: a pilot study. J Sports Med Phys Fitness. doi: https://doi.org/10.23736/S0022-4707.17.07214-0

34.

Sasaki T, Nakajima H (1992) Serum adenosine deaminase activity in systemic sclerosis (scleroderma) and related disorders. J Am Acad Dermatol 27:411–414. https://doi.org/10.1016/0190-9622(92)70209-X CrossRefPubMed

35.

Herken H, Gurel A, Selek S et al (2007) Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment. Arch Med Res 38:247–252CrossRefPubMed

Title: Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren’s syndrome: a pilot study
Authors: Asta Tvarijonaviciute
Carmen Zamora
Silvia Martinez-Subiela
Fernando Tecles
Francisca Pina
Pia Lopez-Jornet
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 3/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2570-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren’s syndrome: a pilot study

Abstract

Objectives

Methods

Results

Conclusion

Clinical relevance

Trial registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Clinical relevance

Trial registration

Please log in to get access to this content

Other articles of this Issue 3/2019

Comparative differentiation analysis of distinct oral tissue-derived cells in response to osteogenic stimulation

Direct oral anticoagulants, vitamin K antagonists, and simple single tooth extraction

Management of deep carious lesions and pulps exposed during carious tissue removal in adults: a questionnaire study among dentists in Finland

Correlation between relative bacterial activity and lactate dehydrogenase gene expression of co-cultures in vitro

Salivary levels and immunohistochemical expression of selected angiogenic factors in benign and malignant parotid gland tumours

Deep sequencing reveals specific bacterial signatures in the subgingival microbiota of healthy subjects