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01-06-2012 | Original Article

Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern

Authors: Reza Saghiri, Niloufar Ghashghai, Shafieh Movaseghi, Pegah Poursharifi, Shohreh Jalilfar, Manijeh Ahmadi Bidhendi, Leila Ghazizadeh, Mina Ebrahimi-Rad

Published in: Rheumatology International | Issue 6/2012

Abstract

Adenosine deaminase (ADA) plays a crucial role in the development and maintenance of normal immune system. So, any immunological imbalances could associate with its altered activity in serum. This study evaluated the activity of total ADA and its isoenzymes in serum of 45 patients with systemic lupus erythematosus (SLE). Included were 23 patients with active SLE, 22 during the inactive phase of the disease, and 45 healthy subjects. Our results provided evidence that the significantly elevated total ADA activity in serum of SLE patients is correlated mainly with the increased ADA2 level. The highest mean ADA2 activity during the relapse phase of the disease could be an indication to the macrophages, the main source of ADA2. It might be concluded that ADA and its isoenzymes analysis in serum of patients could be used as a useful and non-invasive diagnostic tool in evaluation of SLE active phase and the disease severity.

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Title: Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern
Authors: Reza Saghiri
Niloufar Ghashghai
Shafieh Movaseghi
Pegah Poursharifi
Shohreh Jalilfar
Manijeh Ahmadi Bidhendi
Leila Ghazizadeh
Mina Ebrahimi-Rad
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 6/2012
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-011-1836-8

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