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Clinical Oral Investigations

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01-06-2018 | Short Communication

Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis

Authors: Dogukan Yilmaz, Feriha Caglayan, Esra Buber, Eija Könönen, Yasemin Aksoy, Ulvi Kahraman Gursoy, Guliz N. Guncu

Published in: Clinical Oral Investigations | Issue 5/2018

Abstract

Objectives

Human β-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals.

Materials and methods

Altogether, 81 subjects were included in the study: 21 subjects with type 2 diabetes mellitus (T2DM) suffering from generalized periodontitis (T2DM + GP), 18 systemically healthy generalized periodontitis patients (GP), 18 periodontally healthy T2DM subjects (T2DM + H), and 24 systemically and periodontally healthy subjects (control). Plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded, and GCF samples were collected. hBD-1 levels in GCF were measured using ELISA.

Results

hBD-1 levels were significantly reduced in the T2DM + GP and GP groups. Although PI and GI scores were similar in both periodontally healthy groups, hBD-1 levels were lower in the T2DM + H group. In the whole population, hBD-1 levels correlated negatively with all periodontal parameters.

Conclusions

Both diabetes and periodontitis affect hBD-1 levels in GCF.

Clinical relevance

The altered levels of hBD-1 in GCF of diabetics might be associated with the susceptibility of diabetics to periodontitis.

PCP-15, HuFriedy, Chicago, IL, USA

Orthopantomograph OP 100, Sirona Orthophos XG5, NY, USA

Periopaper, Interstate Drug Exchange, Amityville, NY, USA

Periotron 8000, Oraflow Inc., Plainview, NY, USA

EiAAb/Uscn, Wuhan, China

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Title: Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis
Authors: Dogukan Yilmaz
Feriha Caglayan
Esra Buber
Eija Könönen
Yasemin Aksoy
Ulvi Kahraman Gursoy
Guliz N. Guncu
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 5/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2469-z

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Springer Medicine

Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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