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Open Access 01-09-2017 | Original Article

Permanent tooth agenesis in non-syndromic Robin sequence and cleft palate: prevalence and patterns

Authors: Anneline de Smalen, Daan P. F. van Nunen, Ruurd R. Hermus, Edwin M. Ongkosuwito, Arjen J. van Wijk, J. Peter W. Don Griot, Corstiaan C. Breugem, Gem J. C. Kramer

Published in: Clinical Oral Investigations | Issue 7/2017

Abstract

Objectives

Partial tooth agenesis is frequently observed in Robin sequence. Tooth anomalies are increasingly considered as an extended phenotype of the cleft palate population. The study objective was to compare the prevalence and patterns of tooth agenesis in a group of patients with non-syndromic Robin sequence (ns-RS) and a group with non-syndromic cleft palate (ns-CP).

Materials and methods

The panoramic radiographs of 115 ns-RS and 191 ns-CP patients were assessed for agenesis of the permanent dentition (excluding third molars) and the patterns recorded using the Tooth Agenesis Code.

Results

Partial tooth agenesis was observed in 47.8% of ns-RS and 29.8% of ns-CP patients with a greater prevalence in the mandibula than in the maxilla, particularly in ns-RS. The teeth most frequently absent in both groups were the mandibular second premolars and maxillary lateral incisors. Tooth agenesis was bilateral in two-thirds of affected ns-RS patients and one-half of ns-CP patients. In ns-RS, bilateral agenesis of the mandibular second premolars was more frequently observed in female than that in male patients. Completely symmetrical patterns of hypodontia were found in around 45% of ns-RS patients with tooth agenesis compared to 35% in ns-CP. No association was found between the extent of the palatal cleft and the severity of hypodontia.

Conclusion

Tooth agenesis is more prevalent in ns-RS than that in ns-CP, demonstrates a much greater predilection for the mandible in ns-RS, and bears no relation to the extent of the palatal cleft.

Clinical relevance

When compared to ns-CP, additional developmental disturbances are likely involved in the etiology of tooth agenesis in ns-RS. Future research could help identify the underlying genetic traits and aid in classifying patients in those with and without expected tooth agenesis in order to facilitate orthodontic management strategies.

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Title: Permanent tooth agenesis in non-syndromic Robin sequence and cleft palate: prevalence and patterns
Authors: Anneline de Smalen
Daan P. F. van Nunen
Ruurd R. Hermus
Edwin M. Ongkosuwito
Arjen J. van Wijk
J. Peter W. Don Griot
Corstiaan C. Breugem
Gem J. C. Kramer
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 7/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-2020-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Permanent tooth agenesis in non-syndromic Robin sequence and cleft palate: prevalence and patterns

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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