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Clinical Oral Investigations
Published in: Clinical Oral Investigations 2/2015

01-03-2015 | Original Article

Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis

Authors: Rakefet Czerninski, Anna Pikovsky, Irith Gati, Michael Friedman, Doron Steinberg

Published in: Clinical Oral Investigations | Issue 2/2015

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Abstract

Objectives

Candida albicans is a common fungal infection and is commensal in 40–65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis.

Materials and methods

Of the 12 patients with denture stomatitis treated for 14 days, six used Clot-SRV (study group) and six clotrimazole troches (control). The patients were instructed to use Clot-SRV (50 mg of clotrimazole) once a day, and the control group was instructed to use five troches of 10 mg clotrimazole/day. Microbiological samples were obtained from saliva, buccal mucosa, palate, and denture. The degree of erythema was recorded at three time points, and subjective opinions noted using a questionnaire.

Results

At the end of the study, the control group had relatively more cases of erythema on all examined surfaces; patients who applied the Clot-SRV had significantly lower levels of candida on the denture surfaces and in saliva, and had better compliance to the medication.

Conclusions

The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes.
Literature
1.
Rex JH, Walsh TJ, Sobel JD, Filler SG, Pappas PG, Dismukes WE, Edwards JE (2000) Practice guidelines for the treatment of candidiasis. Clin Infect Dis 30:662–678CrossRefPubMed
2.
Ellepola ANB, Samaranayake LP (2000) Oral candidal infections and antimycotics. Crit Rev Oral Biol Med 11:172–198CrossRefPubMed
3.
Zegarelli DJ (1993) Fungal infections of the oral cavity. Otolaryngol Clin North Am 26:1069–1089PubMed
4.
Gonsalves WC, Wrightson AS, Henry RG (2008) Common oral conditions in older persons. Am Fam Physician 78:845–852PubMed
5.
Samaranayake LP, Cheung L, Samaranayake YH (2002) Candidiasis and other fungal diseases of the mouth. Dermatol Ther 15:251–269CrossRef
6.
van Roey J, Haxaire M, Kamya M, Lwanga I, Katabira E (2004) Comparative efficacy of topical therapy with a slow-release mucoadhesive buccal tablet containing miconazole nitrate versus systemic therapy with ketoconazole in HIV-positive patients with oropharyngeal candidiasis. J Acquir Immune Defic Syndr 35:144–150CrossRefPubMed
7.
Köstler WJ, Hejna M, Wenzel C, Zielinski CC (2001) Oral mucositis complicating chemotherapy and/or radiotherapy: options for prevention and treatment. CA Cancer J Clin 51:290–315CrossRefPubMed
8.
Ruskin JD, Wood RP, Bailey MR, Whitmore CK, Shaw BW (1992) Comparative trial of oral clotrimazole and nystatin for oropharyngeal candidiasis prophylaxis in orthotopic liver transplant patients. Oral Surg Oral Med Oral Pathol 74:567–571CrossRefPubMed
9.
Worthington HV, Clarkson JE (2002) Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: Cochrane systematic review. J Dent Educ 66:903–910PubMed
10.
Vyas SP, Sihorkar V, Mishra V (2000) Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. J Clin Pharm Ther 25:21–42CrossRefPubMed
11.
Steinberg D, Tal T, Friedman M (2006) Sustained-release delivery systems of triclosan for treatment of Streptococcus mutans biofilm. J Biomed Mater Res B Appl Biomater 77:282–286CrossRefPubMed
12.
Friedman M, Steinberg D (1990) Sustained-release delivery systems for treatment of dental diseases. Pharm Res 7:313–317CrossRefPubMed
13.
Steinberg D, Moldovan M, Molukandov D (2001) Testing a degradable topical varnish of cetylpyridinium chloride in an experimental dental biofilm model. J Antimicrob Chemother 48:241–243CrossRefPubMed
14.
Steinberg D, Rozen R, Klausner EA, Zachs B, Friedman M (2002) Formulation, development and characterization of sustained release varnishes containing amine and stannous fluorides. Caries Res 36:411–416CrossRefPubMed
15.
Czerninski R, Sivan S, Steinberg D, Gati I, Kagan L, Friedman M (2010) A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. Clin Oral Invest 14:71–78CrossRef
16.
Marcos-Arias C, Vicente JL, Sahand IH, Eguia A, De-Juan A, Madariaga L, Aguirre JM, Eraso E, Quindós G (2009) Isolation of Candida dubliniensis in denture stomatitis. Arch Oral Biol 54:127–131CrossRefPubMed
17.
Navazesh M, Kumar SKS (2008) Measuring salivary flow. Challenges and opportunities. JADA 139:35S–40SPubMed
18.
Borhan MK, Mosallaie S, Torkman M (2006) Oral manifestation and salivary alterations in patients with endstage renal disease. J Qazvin Univ Med Sci Heakth Serv 10:17–20
19.
Figueiral MH, Azul A, Pinto E, Fonseca PA, Branco FM, Scully C (2007) Denture-related stomatitis: identification of aetiological and predisposing factors—a large cohort. J Oral Rehabil 34:448–455CrossRefPubMed
20.
Haveman CW (2004) Xerostomia management in the head and neck radiation patient. Tex Dent J 121:483–497PubMed
21.
22.
Powderly WG, Gallant JE, Ghannoum MA, Mayer KH, Navarro EE, Perfect JR (1999) Oropharyngeal candidiasis in patients with HIV: suggested guidelines for therapy. AIDS Res Hum Retroviruses 15:1619–1623CrossRefPubMed
23.
Dias AP, Samaranayake LP, Lee MT (1997) Miconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients. Clin Oral Investig 1:47–52CrossRefPubMed
24.
Parvinen T, Kokko J, Yli-Urpo A (1994) Miconazole lacquer compared with gel in treatment of denture stomatitis. Scand J Dent Res 102:361–366PubMed
25.
Salerno C, Pascale M, Contaldo M, Esposito V, Busciolano M, Milillo L, Guida A, Petruzzi M, Serpico R (2011) Candida-associated denture stomatitis. Med Oral Patol Oral Cir Bucal 16:e139–e143CrossRefPubMed
26.
27.
Pemberton MN, Oliver RJ, Theaker ED (2004) Miconazole oral gel and drug interactions. Brit Dentl J 196:529–531CrossRef
28.
Sholapurkar AA, Pai KM, Rao S (2009) Comparison of efficacy of fluconazole mouthrinse and clotrimazole mouthpaint in the treatment of oral candidiasis. Aust Dental J 54:341–346CrossRef
29.
Pinto E, Ribeiro IC, Ferreira NJ, Fortes CE, Fonseca PA, Figueiral MH (2008) Correlation between enzyme production, germ tube formation and susceptibility to fluconazole in Candida species isolated from patients with denture-related stomatitis and control individuals. J Oral Pathol Med 37:587–592CrossRefPubMed
30.
Barbeau J, Seguin J, Goulet JP, de Koninck L, Lalonde B, Rompre P, Deslaurjers N (2003) Reassessing the presence of Candida albicans in denture-related stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:51–59CrossRefPubMed
31.
Silva MM, de Oliveira M, Colombo AL, Sanita PV, Jorge JH, Massucato EMS, Vergani CE (2012) Comparison of denture microwave disinfection and conventional antifungal therapy in the treatment of denture stomatitis: a randomized clinical study. Oral Surg Oral Med Oral Pathol Oral Radiol 114:469–479CrossRefPubMed
32.
Pereira- Cenci T, Del Bel Cuty AA, Crielaard W, Ten Cate JM (2008) Development of Candida-associated denture stomatitis: new insights. J Appl Oral Sci 16:86–94CrossRefPubMed
33.
34.
World Health Organization (2001) Adherence to long-term therapies: policy for action. WHO/MNC/CCH/01.02
Metadata
Title
Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis
Authors
Rakefet Czerninski
Anna Pikovsky
Irith Gati
Michael Friedman
Doron Steinberg
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 2/2015
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-014-1259-5

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