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Clinical Oral Investigations

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01-12-2014 | Original Article

Analysis of reasons for osteonecrosis of the jaws

Authors: Christian Walter, Keyvan Sagheb, Jennifer Bitzer, Roman Rahimi-Nedjat, Katherine Joyce Taylor

Published in: Clinical Oral Investigations | Issue 9/2014

Abstract

Purpose

Osteonecroses of the jaws are caused by several reasons. Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is known since 2003 with an increasing incidence in the first years. Along with more knowledge about the pathophysiology, preventive strategies were implemented trying to reduce the incidence. The aim of this retrospective study was to analyze the frequency and overall proportion of BP-ONJ within the field of osteonecrosis. The data was compared to a similar study performed in 2005.

Methods

All patients with osteonecrosis or osteomyelitis treated in the period from April 2005 to July 2012 in the Oral and Maxillofacial Surgery at the University of Mainz, Germany, were analyzed.

Results

The reasons for osteonecrosis were bisphosphonates in 45 %, odontogenic or surgically induced osteonecrosis in 32 %, osteoradionecrosis in 17 %, traumas in 1 %, and in 4 % the reason remained unclear. The BP-ONJ became the most important factor for osteonecrosis. Its fraction in the years 2000–2005 was 10 % only.

Conclusions

Although preventive strategies are implemented, the number of new cases got bigger. The implemented prevention strategies did not manage to reduce the overall number of new cases. Furthermore, the launch of other medications with a similar side effect on the jawbone as the BP-ONJ for bisphosphonates might influence the overall distribution of osteonecroses.

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Title: Analysis of reasons for osteonecrosis of the jaws
Authors: Christian Walter
Keyvan Sagheb
Jennifer Bitzer
Roman Rahimi-Nedjat
Katherine Joyce Taylor
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 9/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-014-1205-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Analysis of reasons for osteonecrosis of the jaws

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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