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01-10-2011 | Original Article

Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis

Authors: Mohit Sharma, Indira Bairy, Keerthilatha Pai, Kapaettu Satyamoorthy, Shailendra Prasad, Barry Berkovitz, Raghu Radhakrishnan

Published in: Clinical Oral Investigations | Issue 5/2011

Abstract

The development of oral cancer proceeds through discrete molecular changes that are acquired from loss of genomic integrity after continued exposure to environmental risk factors. It is preceded in the majority of cases by clinically evident oral potentially malignant disorders, the most common of which is leukoplakia. Early detection of these oral lesions by screening methods using suitable markers is critical as it mirrors molecular alterations, long before cancer phenotypes are manifested. Assessment of salivary interleukin-6 (IL-6) as a marker of malignant progression was undertaken in patients with leukoplakia having coexisting periodontitis (n = 20), periodontitis patients without leukoplakia (n = 20), and healthy controls (n = 20) by competitive enzyme-linked immunosorbent assay. Results showed elevation of IL-6 levels in leukoplakia with coexisting periodontitis and in periodontitis patients when compared to healthy control (P < 0.001). Within the leukoplakia group, IL-6 level was found to be increased with increase in the severity of dysplasia. The use of tobacco was seen to play a significant role in the elevation of salivary IL-6.The importance of IL-6 as a specific marker for leukoplakia with dysplasia and the role of tobacco as an independent risk factor has been highlighted.

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Title: Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis
Authors: Mohit Sharma
Indira Bairy
Keerthilatha Pai
Kapaettu Satyamoorthy
Shailendra Prasad
Barry Berkovitz
Raghu Radhakrishnan
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 5/2011
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-010-0435-5

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Springer Medicine

Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis

Abstract

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Abstract

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