Skip to main content
Top
Published in: Clinical Oral Investigations 5/2011

01-10-2011 | Original Article

Periodontal therapy and risk for adverse pregnancy outcomes

Authors: Alcione Maria Soares Dutra Oliveira, Peterson Antonio Dutra de Oliveira, Luís Otávio Miranda Cota, Claúdia Silami Magalhães, Allyson Nogueira Moreira, Fernando Oliveira Costa

Published in: Clinical Oral Investigations | Issue 5/2011

Login to get access

Abstract

Periodontitis has been associated with adverse pregnancy outcomes. Results from intervention studies are few and controversial. The present study assessed the effects of non-surgical periodontal treatment in the occurrence of adverse pregnancy outcomes. Two hundred forty-six eligible women were randomly divided into two groups: periodontitis intervention (n = 122; undergoing non-surgical treatment during gestation) and periodontitis control (n = 124; not treated during gestation). Univariate analysis was performed and estimates of relative risk were reported. Data from 225 women were analyzed. No differences for preterm birth (p = 0.721), low birth weight (p = 0.198), and preterm low birth weight (p = 0.732) rates were observed. Relative risk estimates for preterm birth, low birth weight, and preterm low birth weight in the periodontitis intervention group were 0.915 (95% CI 0.561–1.493), 0.735 (95% CI 0.459–1.179), and 0.927 (0.601–1.431), respectively. Non-surgical periodontal treatment during the second semester of gestation did not reduce the risk for preterm birth, low birth weight, and preterm low birth weight.
Literature
1.
go back to reference Hasegawa K, Furuichi Y, Shimotsu A, Nakamura M, Yoshinaga M, Kamitomo Hatae M, Maruyama I, Izumi Y (2003) Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J Periodontol 74:1764–1770PubMedCrossRef Hasegawa K, Furuichi Y, Shimotsu A, Nakamura M, Yoshinaga M, Kamitomo Hatae M, Maruyama I, Izumi Y (2003) Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J Periodontol 74:1764–1770PubMedCrossRef
2.
go back to reference Goldenberg MD, Culhane JF (2006) Preterm birth and periodontal disease. N Eng J Med 355:1925–1927CrossRef Goldenberg MD, Culhane JF (2006) Preterm birth and periodontal disease. N Eng J Med 355:1925–1927CrossRef
3.
go back to reference Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, McKaig R, Beck J (1996) Periodontal infection as possible risk factor for preterm low birth weight. J Periodontol 67(suppl):1103–1113PubMed Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, McKaig R, Beck J (1996) Periodontal infection as possible risk factor for preterm low birth weight. J Periodontol 67(suppl):1103–1113PubMed
4.
go back to reference Dörtbudak O, Eberhardt R, Ulm M, Persson GR (2005) Periodontitis, a marker of risk in pregnancy for preterm birth. J Clin Periodontol 32:45–52PubMedCrossRef Dörtbudak O, Eberhardt R, Ulm M, Persson GR (2005) Periodontitis, a marker of risk in pregnancy for preterm birth. J Clin Periodontol 32:45–52PubMedCrossRef
5.
go back to reference Santos-Pereira SA, Giraldo PC, Saba-Chujfi E, Amaral RL, Morais SS, Fachini AM, Gonçalves AK (2007) Chronic periodontitis pre-term labour in Brazilian pregnant women: association to be analyzed. J Clin Periodontol 34:208–213PubMedCrossRef Santos-Pereira SA, Giraldo PC, Saba-Chujfi E, Amaral RL, Morais SS, Fachini AM, Gonçalves AK (2007) Chronic periodontitis pre-term labour in Brazilian pregnant women: association to be analyzed. J Clin Periodontol 34:208–213PubMedCrossRef
6.
go back to reference Siqueira FM, Cota LOM, Costa JE, Haddad JPA, Lana AMQ, Costa FO (2007) Intrauterine growth restriction, low birth weight, and preterm birth: adverse pregnancy outcomes and their association with maternal periodontitis. J Periodontol 78:2266–2276PubMedCrossRef Siqueira FM, Cota LOM, Costa JE, Haddad JPA, Lana AMQ, Costa FO (2007) Intrauterine growth restriction, low birth weight, and preterm birth: adverse pregnancy outcomes and their association with maternal periodontitis. J Periodontol 78:2266–2276PubMedCrossRef
7.
go back to reference Toygar HU, Seydaoglu G, Kurklu S, Guzeldemir E, Arpak N (2007) Periodontal health and adverse pregnancy outcome in 3,576 Turkish women. J Periodontol 78:2081–2094PubMedCrossRef Toygar HU, Seydaoglu G, Kurklu S, Guzeldemir E, Arpak N (2007) Periodontal health and adverse pregnancy outcome in 3,576 Turkish women. J Periodontol 78:2081–2094PubMedCrossRef
8.
go back to reference Agueda A, Ramón JM, Manau C, Guerrero A, Echeverría JJ (2008) Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. J Clin Periodontol 35:16–22PubMed Agueda A, Ramón JM, Manau C, Guerrero A, Echeverría JJ (2008) Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. J Clin Periodontol 35:16–22PubMed
9.
go back to reference Mitchell-Lewis D, Engebretson SP, Chen J, Lamster IB, Papapanou PN (2001) Periodontal infections and pre-term birth: early findings from a cohort of young minority women in New York. Eur J Oral Sci 109:34–39PubMedCrossRef Mitchell-Lewis D, Engebretson SP, Chen J, Lamster IB, Papapanou PN (2001) Periodontal infections and pre-term birth: early findings from a cohort of young minority women in New York. Eur J Oral Sci 109:34–39PubMedCrossRef
10.
go back to reference Davenport ES, Williams CECS, Sterne JAC, Murad S, Sivapathasundram V, Curtis MA (2002) Maternal periodontal disease and preterm low birthweight: case control study. J Dent Res 81:313–318PubMedCrossRef Davenport ES, Williams CECS, Sterne JAC, Murad S, Sivapathasundram V, Curtis MA (2002) Maternal periodontal disease and preterm low birthweight: case control study. J Dent Res 81:313–318PubMedCrossRef
11.
go back to reference Noack B, Klingenberg J, Weigelt J, Hoffman T (2005) Periodontal status and preterm low birth weight: a case control study. J Periodontal Res 40:339–345PubMedCrossRef Noack B, Klingenberg J, Weigelt J, Hoffman T (2005) Periodontal status and preterm low birth weight: a case control study. J Periodontal Res 40:339–345PubMedCrossRef
12.
go back to reference Collins JG, Windley HW 3rd, Arnold RR, Offenbacher S (1994) Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in the hamster. Infect Immun 62:4356–4361PubMed Collins JG, Windley HW 3rd, Arnold RR, Offenbacher S (1994) Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in the hamster. Infect Immun 62:4356–4361PubMed
13.
go back to reference Yeo A, Smith MA, Lin D, Riché EL, Moore A, Elter J, Offenbacher S (2005) Campylobacter rectus mediates growth restriction in pregnant mice. J Periodontol 76:551–557PubMedCrossRef Yeo A, Smith MA, Lin D, Riché EL, Moore A, Elter J, Offenbacher S (2005) Campylobacter rectus mediates growth restriction in pregnant mice. J Periodontol 76:551–557PubMedCrossRef
14.
go back to reference Offenbacher S, Riché EL, Barros SP, Bobetsis YA, Lin D, Beck JD (2005) Effects of maternal Campylobacter rectus infection on murine placenta, fetal and neonatal survival, and brain development. J Periodontol 76(suppl):2133–2143PubMedCrossRef Offenbacher S, Riché EL, Barros SP, Bobetsis YA, Lin D, Beck JD (2005) Effects of maternal Campylobacter rectus infection on murine placenta, fetal and neonatal survival, and brain development. J Periodontol 76(suppl):2133–2143PubMedCrossRef
15.
go back to reference Lopez NJ, Smith PC, Gutierrez J (2002) Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial. J Periodontol 73:911–924PubMedCrossRef Lopez NJ, Smith PC, Gutierrez J (2002) Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial. J Periodontol 73:911–924PubMedCrossRef
16.
go back to reference Lopez NJ, Da Silva I, Ipinza J, Gutierrez J (2005) Periodontal therapy reduces the rate of preterm low birth weight in women with pregnancy-associated gingivitis. J Periodontol 76(suppl):2144–2153PubMedCrossRef Lopez NJ, Da Silva I, Ipinza J, Gutierrez J (2005) Periodontal therapy reduces the rate of preterm low birth weight in women with pregnancy-associated gingivitis. J Periodontol 76(suppl):2144–2153PubMedCrossRef
17.
go back to reference Offenbacher S, Lin D, Strauss R, McKaig R, Irving J, Barros SP, Moss K, Barrow DA, Hefti A, Beck JD (2006) Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study. J Periodontol 77:2011–2024PubMedCrossRef Offenbacher S, Lin D, Strauss R, McKaig R, Irving J, Barros SP, Moss K, Barrow DA, Hefti A, Beck JD (2006) Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study. J Periodontol 77:2011–2024PubMedCrossRef
18.
go back to reference Gazolla CM, Ribeiro A, Moysés MR, Oliveira LAM, Pereira LJ, Sallum AW (2007) Evaluation of the incidence of preterm low birth weight in patients undergoing periodontal therapy. J Periodontol 78:842–848PubMedCrossRef Gazolla CM, Ribeiro A, Moysés MR, Oliveira LAM, Pereira LJ, Sallum AW (2007) Evaluation of the incidence of preterm low birth weight in patients undergoing periodontal therapy. J Periodontol 78:842–848PubMedCrossRef
19.
go back to reference Jeffcoat MK, Hauth JC, Geurs NC, Reddy MS, Oliver SP, Hodgkins PM, Goldenberg RL (2003) Periodontal disease and preterm birth: results of pilot intervention. J Periodontol 74:1214–1218PubMedCrossRef Jeffcoat MK, Hauth JC, Geurs NC, Reddy MS, Oliver SP, Hodgkins PM, Goldenberg RL (2003) Periodontal disease and preterm birth: results of pilot intervention. J Periodontol 74:1214–1218PubMedCrossRef
20.
go back to reference Michalowicz BS, Hodges JS, Diangelis AJ, Lupo VR, Novak MJ, Ferguson JE, Buchanan W, Biofill J, Papapanou PN, Mitchell DA, Matseoane S, Tschide PA (2006) Treatment of periodontal disease and the risk of preterm birth. N Engl J Med 355:1885–1894PubMedCrossRef Michalowicz BS, Hodges JS, Diangelis AJ, Lupo VR, Novak MJ, Ferguson JE, Buchanan W, Biofill J, Papapanou PN, Mitchell DA, Matseoane S, Tschide PA (2006) Treatment of periodontal disease and the risk of preterm birth. N Engl J Med 355:1885–1894PubMedCrossRef
21.
go back to reference Ferguson JE 2nd, Hansen WF, Novak KF, Novak MJ (2007) Should we treat periodontal disease during gestation to improve pregnancy outcomes? Clin Obstet Gynecol 50:454–467PubMedCrossRef Ferguson JE 2nd, Hansen WF, Novak KF, Novak MJ (2007) Should we treat periodontal disease during gestation to improve pregnancy outcomes? Clin Obstet Gynecol 50:454–467PubMedCrossRef
22.
go back to reference World Health Organization (1992) International statistical classification of diseases and related health problems. World Health Organization, Geneva World Health Organization (1992) International statistical classification of diseases and related health problems. World Health Organization, Geneva
23.
go back to reference Wimmer G, Pihlstrom BL (2008) A critical assessment of adverse pregnancy outcome and periodontal disease. J Clin Periodontol 35(suppl):380–397PubMedCrossRef Wimmer G, Pihlstrom BL (2008) A critical assessment of adverse pregnancy outcome and periodontal disease. J Clin Periodontol 35(suppl):380–397PubMedCrossRef
24.
go back to reference Jeffcoat MK, Hauth JC, Geurs NC et al (2003) Periodontal disease and preterm birth: results of pilot intervention. J Periodontol 74:1214–1218PubMedCrossRef Jeffcoat MK, Hauth JC, Geurs NC et al (2003) Periodontal disease and preterm birth: results of pilot intervention. J Periodontol 74:1214–1218PubMedCrossRef
25.
go back to reference Tarannum F, Faizuddin M (2007) Effect of periodontal therapy on pregnancy outcome in women affected by periodontitis. J Periodontol 78:2095–2103PubMedCrossRef Tarannum F, Faizuddin M (2007) Effect of periodontal therapy on pregnancy outcome in women affected by periodontitis. J Periodontol 78:2095–2103PubMedCrossRef
26.
go back to reference Offenbacher S, Beck J (2007) Has periodontal treatment failed to reduce adverse pregnancy outcomes? The answer may be premature. J Periodontol 78:95–197 Offenbacher S, Beck J (2007) Has periodontal treatment failed to reduce adverse pregnancy outcomes? The answer may be premature. J Periodontol 78:95–197
27.
go back to reference Kinane D, Bouchard P (2008) Periodontal diseases and health: consensus report of the Sixth European Workshop on Periodontology. J Clin Periodontol 35(suppl):333–337PubMedCrossRef Kinane D, Bouchard P (2008) Periodontal diseases and health: consensus report of the Sixth European Workshop on Periodontology. J Clin Periodontol 35(suppl):333–337PubMedCrossRef
28.
go back to reference Manau C, Echeverria A, Agueda A, Guerrero A, Echeverria JJ (2008) Periodontal disease definition may determine the association between periodontitis and pregnancy outcomes. J Clin Periodontol 35:385–397PubMedCrossRef Manau C, Echeverria A, Agueda A, Guerrero A, Echeverria JJ (2008) Periodontal disease definition may determine the association between periodontitis and pregnancy outcomes. J Clin Periodontol 35:385–397PubMedCrossRef
29.
go back to reference Novak MJ, Novak KF, Hodges JS, Kirakodu S, Govindaswami M, DiAngelis A, Buchanan W, Papapanou PN, Michalowicz BS (2008) Periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol 79:1870–1879PubMedCrossRef Novak MJ, Novak KF, Hodges JS, Kirakodu S, Govindaswami M, DiAngelis A, Buchanan W, Papapanou PN, Michalowicz BS (2008) Periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol 79:1870–1879PubMedCrossRef
Metadata
Title
Periodontal therapy and risk for adverse pregnancy outcomes
Authors
Alcione Maria Soares Dutra Oliveira
Peterson Antonio Dutra de Oliveira
Luís Otávio Miranda Cota
Claúdia Silami Magalhães
Allyson Nogueira Moreira
Fernando Oliveira Costa
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Clinical Oral Investigations / Issue 5/2011
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-010-0424-8

Other articles of this Issue 5/2011

Clinical Oral Investigations 5/2011 Go to the issue