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Journal of Orthopaedic Science

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01-01-2011 | Original article

The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia

Authors: David J. Hak, Kurt S. Schulz, Behrang Khoie, Scott J. Hazelwood

Published in: Journal of Orthopaedic Science | Issue 1/2011

Abstract

Objective

The purpose of this study was to evaluate the effect of Cox-2 administration on direct (primary) fracture healing.

Methods

A transverse tibial osteotomy was created in adult male rabbits and rigidly fixed in compression using a 2.7-mm dynamic compression plate. Animals were randomized to receive either rofecoxib (12.5 mg orally per day) or placebo. Animals were killed at 4 weeks and fracture healing assessed by mechanical testing.

Results

There were no significant differences between the control and Cox-2 treated animals in terms of mechanical strength at 4 weeks. There was a high complication rate of peri-implant fractures during the daily medication administration.

Conclusion

The immediate administration of a Cox-2 specific inhibitor did not impair primary (direct) bone healing at the dose administered in this rabbit tibial osteotomy model.

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Title: The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia
Authors: David J. Hak
Kurt S. Schulz
Behrang Khoie
Scott J. Hazelwood
Publication date: 01-01-2011
Publisher: Springer Japan
Published in: Journal of Orthopaedic Science / Issue 1/2011
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-010-0016-0

At a glance: The STEP trials

Springer Medicine

The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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