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01-01-2014 | Original Article

Trabecular bone structure analysis of the spine using clinical MDCT: can it predict vertebral bone strength?

Authors: Thomas Baum, Martin Gräbeldinger, Christoph Räth, Eduardo Grande Garcia, Rainer Burgkart, Janina M. Patsch, Ernst J. Rummeny, Thomas M. Link, Jan S. Bauer

Published in: Journal of Bone and Mineral Metabolism | Issue 1/2014

Abstract

Recent technical improvements have made it possible to determine trabecular bone structure parameters of the spine using clinical multi-detector computed tomography (MDCT). Therefore, the purpose of this study was to analyze trabecular bone structure parameters obtained from clinical MDCT in relation to high resolution peripheral quantitative computed tomography (HR-pQCT) as a standard of reference and to investigate whether clinical MDCT can predict vertebral bone strength. Fourteen functional spinal segment units between T7 and L3 were harvested from 14 formalin-fixed human cadavers (11 women and 3 men; age 84 ± 10 years). All functional spinal segment units were examined using HR-pQCT (isotropic voxel size of 41 μm³) and a clinical whole-body MDCT (interpolated voxel size of 146 × 146 × 300 μm³). Trabecular bone structure analyses (histomorphometric and texture measures) were performed in the HR-pQCT as well as MDCT images. Vertebral failure load (FL) of the functional spinal segment units was determined in an uniaxial biomechanical test. The HR-pQCT and MDCT derived trabecular bone structure parameters showed correlations ranging from r = 0.60 to r = 0.90 (p < 0.05). Correlations between trabecular bone structure parameters and FL amounted up to r = 0.86 (p < 0.05) using the HR-pQCT images, and up to r = 0.79 (p < 0.05) using the MDCT images. Correlation coefficients of FL versus trabecular bone structure parameters obtained with HR-pQCT and MDCT were not significantly different (p > 0.05). In this cadaver model, the spatial resolution of clinically available whole-body MDCT scanners was suitable for trabecular bone structure analysis of the spine and to predict vertebral bone strength.

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Title: Trabecular bone structure analysis of the spine using clinical MDCT: can it predict vertebral bone strength?
Authors: Thomas Baum
Martin Gräbeldinger
Christoph Räth
Eduardo Grande Garcia
Rainer Burgkart
Janina M. Patsch
Ernst J. Rummeny
Thomas M. Link
Jan S. Bauer
Publication date: 01-01-2014
Publisher: Springer Japan
Published in: Journal of Bone and Mineral Metabolism / Issue 1/2014
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-013-0465-6

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