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01-09-2009 | Review Article

Osteoclasts and the immune system

Authors: Tomoki Nakashima, Hiroshi Takayanagi

Published in: Journal of Bone and Mineral Metabolism | Issue 5/2009

Abstract

Investigation into arthritis as well as the numerous bone phenotypes found in mice lacking immune-related genes has highlighted the importance of the dynamic interplay between the bone and immune systems. It has recently led to both the emergence and subsequent rapid evolution of the field of osteoimmunology. Receptor activator of nuclear factor-κB ligand (RANKL) stimulates osteoclastogenesis through the nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), which is well known as a crucial regulator of immunity. Studies on RANKL signaling revealed various immune-related genes which are involved in the regulation of osteoclastogenesis. Bone destruction in rheumatoid arthritis is caused by the enhanced activity of osteoclasts resulting from the activation of T cells. Here we describe our efforts to address the challenging question as to how abnormal T-cell activation mechanistically induces bone destruction. The scope of osteoimmunology has been extended to encompass a wide range of molecular and cellular interactions, the elucidation of which will provide a scientific basis for future therapeutic approaches to diseases related to both the bone and immune systems.

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Title: Osteoclasts and the immune system
Authors: Tomoki Nakashima
Hiroshi Takayanagi
Publication date: 01-09-2009
Publisher: Springer Japan
Published in: Journal of Bone and Mineral Metabolism / Issue 5/2009
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-009-0089-z

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Bone mass effects of a Smad6 gene polymorphism in Japanese postmenopausal women

Total body, lumbar spine and hip bone mineral density in overweight adolescent girls: decreased or increased?

Spine bone mineral density and VDR polymorphism in subjects with ulcerative colitis

Role of sport and exercise in the maintenance of female bone health

Lower bone mineral density in children with type 1 diabetes is associated with poor glycemic control and higher serum ICAM-1 and urinary isoprostane levels

Relationship between radiological knee osteoarthritis and biochemical markers of cartilage and bone degradation (urine CTX-II and NTX-I): the Matsudai Knee Osteoarthritis Survey

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

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