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01-02-2019 | Original Article

Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand

Authors: Junki Mine, Haruka Abe, Sujira Parchariyanon, Prakit Boonpornprasert, Namfon Ubonyaem, Bandit Nuansrichay, Nobuhiro Takemae, Taichiro Tanikawa, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito

Published in: Archives of Virology | Issue 2/2019

Abstract

Surveillance studies of influenza A virus of swine (IAV-S) have accumulated information regarding IAVs-S circulating in Thailand, but how IAVs-S evolve within a farm remains unclear. In the present study, we isolated 82 A(H1N1)pdm09 and 87 H3N2 viruses from four farms from 2011 through 2017. We then phylogenetically and antigenically analyzed the isolates to elucidate their evolution within each farm. Phylogenetic analysis demonstrated multiple introductions of A(H1N1)pdm09 viruses that resembled epidemic A(H1N1)pdm09 strains in humans in Thailand, and they reassorted with H3N2 viruses as well as other A(H1N1)pdm09 viruses. Antigenic analysis revealed that the viruses had acquired antigenic diversity either by accumulating substitutions in the hemagglutinin protein or through the introduction of IAV-S strains with different antigenicity. Our results, obtained through continuous longitudinal surveillance, revealed that IAV-S can be maintained on a pig farm over several years through the generation of antigenic diversity due to the accumulation of mutations, introduction of new strains, and reassortment events.

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Title: Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand
Authors: Junki Mine
Haruka Abe
Sujira Parchariyanon
Prakit Boonpornprasert
Namfon Ubonyaem
Bandit Nuansrichay
Nobuhiro Takemae
Taichiro Tanikawa
Ryota Tsunekuni
Yuko Uchida
Takehiko Saito
Publication date: 01-02-2019
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 2/2019
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-4091-4

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