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01-11-2017 | Original Article

GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4⁺ T lymphocyte count

Authors: Bárbara Katharine Barbosa de Miranda, Keyla Santos Guedes de Sá, Andrea Nazaré Rangel da Silva, Rosimar Neris Martins Feitosa, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosário Vallinoto

Published in: Archives of Virology | Issue 11/2017

Abstract

GB virus C (GBV-C) is a lymphotropic virus with a low level or non-existent replication in the liver. The interaction between HIV-1 and GBV-C apparently reduces the progression of HIV-1 infection to AIDS and improves the quality of life of HIV-1 infected individuals. A cross-sectional study was established to determine the possible effect of HIV-1/GBV-C coinfection on HIV-1 viral load and CD4⁺ T lymphocyte counts. Samples from 313 HIV-1 infected persons from the Virus Laboratory of the Federal University of Pará as well as demographic and clinical information were obtained from medical records. This study used a nested PCR method to determine GBV-C viremia. The prevalence of HIV-1/GBV-C coinfection was 17%. There were no significant differences in the distribution according to age, sex or ethnicity between the groups. The differences in HIV-1 viral load and CD4⁺ T lymphocyte count between the HIV-1 and HIV-1/GBV-C groups were highly significant, indicating that coinfection results in lower viral loads and higher CD4⁺ T lymphocyte counts compared to HIV-1 mono-infection. The results indicate a protective effect among coinfected individuals.

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Title: GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4+ T lymphocyte count
Authors: Bárbara Katharine Barbosa de Miranda
Keyla Santos Guedes de Sá
Andrea Nazaré Rangel da Silva
Rosimar Neris Martins Feitosa
Izaura Maria Vieira Cayres-Vallinoto
Ricardo Ishak
Antonio Carlos Rosário Vallinoto
Publication date: 01-11-2017
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 11/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3514-y

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