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Archives of Virology
Published in: Archives of Virology 7/2017

01-07-2017 | Brief Report

Cloning, sequencing and characterization of the genome of a recombinant norovirus of the rare genotype GII.P7/GII.6 in China

Authors: Hui Cai, Yongxin Yu, Miao Jin, Yingjie Pan, Shuling Yan, Yongjie Wang

Published in: Archives of Virology | Issue 7/2017

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Abstract

The genome sequence of a rare recombinant norovirus (NoV) genotype obtained from clinical samples in China was determined using one-step reverse transcription PCR. It was identified as the GII.P7/GII.6 genotype using both phylogenetic and SimPlot analyses. A high degree of variability was observed in the P2 subdomain, especially in the B-loop structure. The recombination breakpoints of all available GII.P7/GII.6 strains were mapped to two different positions within the RdRp region, both of which were at least 40 nt upstream of the overlap of ORF1 and 2. The GII.P7/GII.6 genotype appears to have been circulating in Asia for at least 10 years.
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Metadata
Title
Cloning, sequencing and characterization of the genome of a recombinant norovirus of the rare genotype GII.P7/GII.6 in China
Authors
Hui Cai
Yongxin Yu
Miao Jin
Yingjie Pan
Shuling Yan
Yongjie Wang
Publication date
01-07-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 7/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-017-3325-1

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