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01-03-2017 | Brief Report

Expression of human endogenous retrovirus K and W in babies

Authors: L. H. S. Nali, A. C. S. Oliveira, D. O. Alves, G. S. Caleiro, C. F. Nunes, D. Gerhardt, R. C. M. Succi, Camila M. Romano, D. M. Machado

Published in: Archives of Virology | Issue 3/2017

Abstract

Here we determined the relative expression of HERV-K and W proviruses in HIV infected and non-infected mothers as well as their respective babies up to 1 year-old. HIV-infected mothers, their babies and uninfected control groups presented expression of both HERV-K and HERV-W with relatively high frequency. While the level of HERV-K expression was similar among groups, the level of HERV-W expression in HIV-infected mothers was four-fold higher than the uninfected mothers from the control group (p < 0.01). HERV-W was down regulated in HIV-exposed babies in comparison to non-exposed babies. To our knowledge, this is the first report of HERV transcriptional activity in babies from 0-1 year-old.

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Title: Expression of human endogenous retrovirus K and W in babies
Authors: L. H. S. Nali
A. C. S. Oliveira
D. O. Alves
G. S. Caleiro
C. F. Nunes
D. Gerhardt
R. C. M. Succi
Camila M. Romano
D. M. Machado
Publication date: 01-03-2017
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 3/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-3167-2

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