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01-09-2015 | Original Article

Antiherpes evaluation of soybean isoflavonoids

Authors: D. F. Argenta, I. T. Silva, V. L. Bassani, L. S. Koester, H. F. Teixeira, C. M. O. Simões

Published in: Archives of Virology | Issue 9/2015

Abstract

The antiviral effects of soybean isoflavonoids have been investigated recently, especially those of genistein. It has been reported that this isoflavone is able to inhibit herpes simplex virus (HSV) replication, which is associated with skin and epithelial mucosa infections. The treatment of these infections with antiherpes drugs has resulted in the emergence of resistant viral strains. Based on this evidence, the aim of this study was to investigate the anti-HSV effects of soybean isoflavonoids: daidzein, genistein, glycitein, and coumestrol. Genistein and coumestrol inhibited HSV-1 (KOS and 29R strains, which are acyclovir sensitive and acyclovir resistant, respectively) and HSV-2 (333 strain) replication, whereas no antiviral effects were detected for daidzein and glycitein. The mechanisms of action were evaluated by different methodological strategies. Coumestrol affected the early stages of viral infection, and both compounds were able to reduce HSV-1 protein expression, as well as HSV-2 cell-to-cell spread.

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Title: Antiherpes evaluation of soybean isoflavonoids
Authors: D. F. Argenta
I. T. Silva
V. L. Bassani
L. S. Koester
H. F. Teixeira
C. M. O. Simões
Publication date: 01-09-2015
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 9/2015
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-015-2514-z

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