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Archives of Virology
Published in: Archives of Virology 6/2014

01-06-2014 | Brief Report

Molecular characterization of a rabies virus isolate from a rabid dog in Hanzhong District, Shaanxi Province, China

Authors: Jinghui Zhao, Shuchao Wang, Shoufeng Zhang, Ye Liu, Jinxia Zhang, Fei Zhang, Lijuan Mi, Rongliang Hu

Published in: Archives of Virology | Issue 6/2014

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Abstract

A canine rabies virus, Shaanxi-HZ-6, was isolated in Shaanxi Province, China, in 2009. Its genome has been completely sequenced and found to be closely related to the China I rabies virus strains widely circulating in China. The genomic length was 11,923 base pairs, and the overall organization of the genome was similar to that of other rabies virus isolates. Compared with isolates CQ92 and J, 84 amino acid substitutions (7 in the N gene, 15 in P, 6 in M, 25 in G, 31 in L) were observed in strain Shaanxi-HZ-6. Amino acid substitutions of R264H and V332I were noted in the G protein antigenic site I and site III, respectively. Residue 333 of the G protein, which is considered to be associated with pathogenicity, was Arg in Shaanxi-HZ-6. These and other substitutions may help provide an explanation why the China I lineage strain maintains its prevalence in China.
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Metadata
Title
Molecular characterization of a rabies virus isolate from a rabid dog in Hanzhong District, Shaanxi Province, China
Authors
Jinghui Zhao
Shuchao Wang
Shoufeng Zhang
Ye Liu
Jinxia Zhang
Fei Zhang
Lijuan Mi
Rongliang Hu
Publication date
01-06-2014
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 6/2014
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-013-1941-y

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