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01-03-2013 | Brief Report

NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication

Authors: Amin Mottahedin, Maruthibabu Paidikondala, Harindranath Cholleti, Claudia Baule

Published in: Archives of Virology | Issue 3/2013

Abstract

NF-κB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-κB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-κB, and this activation was found to be mediated through the MyD88 pathway. Infection of IKKβ^−/− murine embryo fibroblasts (MEFs), which are deficient in NF-κB signalling, resulted in lower virus titre, less cytopathic effect, and reduced expression of viral proteins. These findings implicate the MyD88 pathway in EAV-induced NF-κB activation and suggest that NF-κB activation is essential for efficient replication of EAV.

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Title: NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication
Authors: Amin Mottahedin
Maruthibabu Paidikondala
Harindranath Cholleti
Claudia Baule
Publication date: 01-03-2013
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 3/2013
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-012-1515-4

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