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01-11-2012 | Brief Report

Development of a minigenome system for Andes virus, a New World hantavirus

Authors: Kyle S. Brown, Hideki Ebihara, Heinz Feldmann

Published in: Archives of Virology | Issue 11/2012

Abstract

The development of reverse genetics systems for negative-stranded RNA viruses is a rapidly evolving field that has greatly advanced the study of the many different aspects of the viral life cycle. Andes virus (ANDV) is a highly pathogenic hantavirus found in South America that causes hantavirus pulmonary syndrome but to date remains poorly characterized due to the lack of a reverse genetics system for genetic manipulation. Here, we describe the first successful minigenome system for a New World hantavirus, as well as many of the obstacles that still exist in the development of such a system.

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Title: Development of a minigenome system for Andes virus, a New World hantavirus
Authors: Kyle S. Brown
Hideki Ebihara
Heinz Feldmann
Publication date: 01-11-2012
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 11/2012
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-012-1401-0

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