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Archives of Virology
Published in: Archives of Virology 11/2012

Open Access 01-11-2012 | Brief Report

Co-detection in the pathogenesis of severe hand-foot-mouth disease

Authors: Li-Juan Liu, Hong-Mei Xu, Xiu-Jun Li, Jun Wang, Xian-Jun Wang, Shu-Jun Ding, Fang Tang, Jing Wang, Ying-Jie Zhang

Published in: Archives of Virology | Issue 11/2012

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Abstract

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.
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Metadata
Title
Co-detection in the pathogenesis of severe hand-foot-mouth disease
Authors
Li-Juan Liu
Hong-Mei Xu
Xiu-Jun Li
Jun Wang
Xian-Jun Wang
Shu-Jun Ding
Fang Tang
Jing Wang
Ying-Jie Zhang
Publication date
01-11-2012
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 11/2012
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1396-6

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