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01-11-2009 | Brief Report

Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China

Authors: Xiao-yan Li, Jin-ying Chen, Mei Kong, Xu Su, Yan-ping Yi, Ming Zou, Hua Zhang

Published in: Archives of Virology | Issue 11/2009

Abstract

Human metapneumovirus (hMPV) has recently been recognized as an important respiratory pathogen, especially in children. At present, our understanding of the characteristics of hMPV from China is very limited. Nasopharyngeal aspirates were taken from 310 hospitalized pediatric patients. Twenty (6.5%) of them were infected with hMPV, and they all developed pneumonia. Sixty five percent (13/20) of the cases were under 12 months. Phylogenetic analysis of F gene fragments indicated that three sub-genotypes of hMPV(A2a/A2b, B1,B2) circulated in Tianjin and A2b was the predominant subtype. The Vero-E6 cell line was better than LLC-MK2 for hMPV isolation. Three hMPV strains were successfully isolated using the Vero-E6 cell line.

Zar HJ (2002) Respiratory infections in children in developing countries. Pediatr Ann 31:133–138PubMed

Ruiz M, Ewig S, Marcos MA, Martinez JA, Arancibia F, Mensa J, Torres A (1999) Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. Am J Respir Crit Care Med 160:397–405PubMed

van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 7:719–724CrossRefPubMed

Lamb RA, Kolakofsky D (2001) Paramyxoviridae the viruses and their replication. In: Knipe DM, Howley PM (eds) Field’s virology, vol 1, 4th edn. Lippincott Williams and Wilkins, Philadelphia, pp 1305–1340

Ebihara T, Endo R, Kikuta H, Ishiguro N, Ishiko H, Hara M, Takahashi Y, Kobayashi K (2004) Human metapneumovirus infection in Japanese children. J Clin Microbiol 42:126–132CrossRefPubMed

Bastien N, Ward D, Van Caeseele P, Brandt K, Lee SH, McNabb G, Klisko B, Chan E, Li Y (2003) Human metapneumovirus infection in the Canadian population. J Clin Microbiol 41:4642–4646CrossRefPubMed

Samransamruajkit R, Thanasugarn W, Prapphal N, Theamboonlers A, Poovorawan Y (2006) Human metapneumovirus in infants and young children in Thailand with lower repiratory tract infections; molecular characteristics and clinical presentations. J Infect 52:254–263CrossRefPubMed

Esper F, Boucher D, Weibel C, Martinello RA, Kahn JS (2003) Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging resp iratory infection in children. Pediatrics 111:1407–1410CrossRefPubMed

Freymouth F, Vabret A, Legrand L, Eterradossi N, Lafay-Delaire F, Brouard J, Guillois B (2003) Presence of the new human metapneumovirus in French children with bronchiolitis. Pediatr Infect Dis J 22:92–94CrossRefPubMed

10.

Peiris JS, Tang WH, Chan KH, Khong PL, Guan Y, Lau YL, Chiu SS (2003) Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis 9:628–633PubMed

11.

Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Côté S, Peret TC, Erdman DD, Anderson LJ (2002) Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 186:1330–1334CrossRefPubMed

12.

Deffrasnes C, Hamelin M, Boivin G (2007) Human metapneumovirus. Semin Respir Crit Care Med 28:213–221CrossRefPubMed

13.

Viazov S, Ratjen F, Scheidhauer R, Fiedler M, Roggendorf M (2003) High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates. J Clin Microbiol 41:3043–3045CrossRefPubMed

14.

Ludewick HP, Abed Y, van Niekerk N, Boivin G, Klugman KP, Madhi SA (2005) Human metapneumovirus genetic variability, South Africa. Emerg Infect Dis 11:1074–1078PubMed

15.

Mao H, Yang X, Zhao X (2008) Characterization of human metapneumoviruses isolated in Chongqing, China. Chin Med J 121:2254–2257PubMed

16.

Zhu RN, Qian Y, Deng J, Wang F, Hu AZ, Lu J, Cao L, Yuan Y, Cheng HZ (2003) Human metapneumovirus may associate with acute respiratory infections in hospitalized pediatric patients in Beijing, China. Zhonghua Er Ke Za Zhi 41:441–444 (in Chinese)PubMed

17.

García-García ML, Calvo C, Casas I, Bracamonte T, Rellán A, Gozalo F, Tenorio T, Pérez-Breña P (2007) Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5. Pediatr Pulmonol 42:458–464CrossRefPubMed

18.

do Carmo Debur M, Bordignon J, Duarte dos Santos CN, Vidal LR, Nogueira MB, de Almeida SM, Raboni SM (2007) Acute respiratory infection by human metapneumovirus in children in southern Brazil. J Clin Virol 39:59–62CrossRefPubMed

19.

Choi EH, Lee HJ, Kim SJ, Eun BW, Kim NH, Lee JA, Lee JH, Song EK, Kim SH, Park JY, Sung JY (2006) The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000–2005. Clin Infect Dis 43:585–592CrossRefPubMed

20.

Abdullah Brooks W, Erdman D, Terebuh P, Klimov A, Goswami D, Sharmeen AT, Azim T, Luby S, Bridges C, Breiman R (2007) Human metapneumovirus infection among children, Bangladesh. Emerg Infect Dis 13:1611–1613PubMed

21.

Camps M, Ricart S, Dimova V, Rovira N, Muñoz-Almagro C, Garcia JJ, Pons-Odena M, Marcos MA, Pumarola T (2008) Prevalence of human metapneumovirus among hospitalized children younger than 1 year in Catalonia, Spain. J Med Virol 80:1452–1460CrossRefPubMed

22.

Greensill J, McNamara PS, Dove W, Flanagan B, Smyth RL, Hart CA (2003) Human metapneumovirus in severe respiratory syncytial virus broncholitis. Emerg Infect Dis 9:372–375PubMed

23.

Regev L, Hindiyeh M, Shulman LM, Barak A, Levy V, Azar R, Shalev Y, Grossman Z, Mendelson E (2006) Characterization of human metapneumovirus infections in Israel. J Clin Microbiol 44:1484–1489CrossRefPubMed

24.

Sarasini A, Percivalle E, Rovida F, Campanini G, Genini E, Torsellini M, Paolucci S, Baldanti F, Marchi A, Grazia Revello M, Gerna G (2006) Detection and pathogenicity of human metapneumovirus respiratory infection in pediatric Italian patients during a winter–spring season. J Clin Virol 35:59–68CrossRefPubMed

25.

Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE Jr (2004) Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 350:443–450CrossRefPubMed

26.

Peret TC, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus AD, Erdman DD, Anderson LJ (2002) Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis 185:1660–1663CrossRefPubMed

27.

van den Hoogen BG, Herfst S, Sprong L, Cane PA, Forleo-Neto E, de Swart RL, Osterhaus AD, Fouchier RA (2004) Antigenic and genetic variability of human metapneumoviruses. Emerg Infect Dis 10:658–666PubMed

28.

Ljubin-Sternak S, Santak M, Cepin-Bogović J, Baće A, Vojnović G, Mlinarić-Galinović G, Forcić D, Drazenović V, Falsey AR (2008) Detection of genetic lineages of human metapneumovirus in Croatia during the winter season 2005/2006. J Med Virol 80:1282–1287CrossRefPubMed

29.

Huck B, Scharf G, Neumann-Haefelin D, Puppe W, Weigl J, Falcone V (2006) Novel human metapneumovirus sublineage. Emerg Infect Dis 12:147–150PubMed

30.

Abiko C, Mizuta K, Itagaki T, Katsushima N, Ito S, Matsuzaki Y, Okamoto M, Nishimura H, Aoki Y, Murata T, Hoshina H, Hongo S, Ootani K (2007) Outbreak of human metapneumovirus detected by use of the Vero E6 cell line in isolates collected in Yamagata, Japan, in 2004 and 2005. J Clin Microbiol 45:1912–1919CrossRefPubMed

Title: Prevalence of human metapneumovirus in hospitalized children with respiratory tract infections in Tianjin, China
Authors: Xiao-yan Li
Jin-ying Chen
Mei Kong
Xu Su
Yan-ping Yi
Ming Zou
Hua Zhang
Publication date: 01-11-2009
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 11/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-009-0492-8

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