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01-09-2009 | Brief Report

The “human influenza receptor” Neu5Acα2,6Gal is expressed among different taxa of wild birds

Authors: Patrik Ellström, Elsa Jourdain, Oskar Gunnarsson, Jonas Waldenström, Björn Olsen

Published in: Archives of Virology | Issue 9/2009

Excerpt

Influenza A viruses (IAVs) bind glycoconjugate receptors displaying terminal sialic acids on host cells. The virus hemagglutinin (HA) protein mediates adhesion to the cells via the core structure “Neu5Acα2,3(6)Galβ1,3(4)GlcNAcβ1-” where the linkage between the sialic acid and the galactose can be either α2,3 or α2,6 (reviewed by Suzuki [22]). Adhesion to these structures is a crucial first step in the infection process, and several studies have shown that the linkage between the sialic acids and the galactose is a strong determinant of virus host range [3, 22]. However, a switch in receptor tropism from α2,3- to α2,6-sialylated glycans requires only one amino acid substitution in the HA protein (reviewed by Suzuki [22]). …

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Title: The “human influenza receptor” Neu5Acα2,6Gal is expressed among different taxa of wild birds
Authors: Patrik Ellström
Elsa Jourdain
Oskar Gunnarsson
Jonas Waldenström
Björn Olsen
Publication date: 01-09-2009
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 9/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-009-0476-8

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