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Archives of Virology
Published in: Archives of Virology 9/2009

01-09-2009 | Brief Report

Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus

Authors: Daisuke Yamane, Muhammad Atif Zahoor, Yassir Mahgoub Mohamed, Walid Azab, Kentaro Kato, Yukinobu Tohya, Hiroomi Akashi

Published in: Archives of Virology | Issue 9/2009

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Abstract

Our efforts to identify the cellular signaling cascades triggered by bovine viral diarrhea virus (BVDV) infection in MDBK cells revealed marked activation of extracellular signal-regulated kinase 1/2 (ERK). Enhanced phosphorylation of ERK was detected following infection with cytopathogenic (cp) BVDV, but not with noncytopathogenic BVDV. It appears that cp BVDV-induced ERK phosphorylation is caused by oxidative stress, because ERK phosphorylation was inducible by treatment with hydrogen peroxide or serum deprivation and was attenuated by addition of antioxidants. These results indicate that BVDV infection influences the ERK signaling pathway via oxidative stress, depending on the biotype.
Literature
1.
Anderson ME (1998) Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111–112:1–14PubMedCrossRef
2.
Baigent SJ, Zhang G, Fray MD, Flick-Smith H, Goodbourn S, McCauley JW (2002) Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. J Virol 76:8979–8988PubMedCrossRef
3.
Baker JC (1995) The clinical manifestations of bovine viral diarrhea infection. Vet Clin North Am Food Anim Pract 11:425–445PubMed
4.
Bhat NR, Zhang P (1999) Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J Neurochem 72:112–119PubMedCrossRef
5.
Brownlie J, Clarke MC, Howard CJ (1989) Experimental infection of cattle in early pregnancy with a cytopathic strain of bovine virus diarrhoea virus. Res Vet Sci 46:307–311PubMed
6.
Charleston B, Fray MD, Baigent S, Carr BV, Morrison WI (2001) Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with a failure to induce type I interferon. J Gen Virol 82:1893–1897PubMed
7.
Dong J, Ramachandiran S, Tikoo K, Jia Z, Lau SS, Monks TJ (2004) EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death. Am J Physiol Renal Physiol 287:F1049–F1058PubMedCrossRef
8.
Houe H (1995) Epidemiology of bovine viral diarrhea virus. Vet Clin North Am Food Anim Pract 11:521–547PubMed
9.
Huang J, Wu L, Tashiro S, Onodera S, Ikejima T (2006) Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway. J Pharmacol Sci 102:305–313PubMedCrossRef
10.
Jaramillo M, Olivier M (2002) Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5′-monophosphate (cAMP)-dependent pathways: involvement of NF-kappa B, activator protein 1, and cAMP response element binding protein. J Immunol 169:7026–7038PubMed
11.
Jordan R, Wang L, Graczyk TM, Block TM, Romano PR (2002) Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells. J Virol 76:9588–9599PubMedCrossRef
12.
13.
McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773:1263–1284PubMedCrossRef
14.
Nakagami H, Morishita R, Yamamoto K, Taniyama Y, Aoki M, Kim S, Matsumoto K, Nakamura T, Higaki J, Ogihara T (2000) Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells. J Hypertens 18:1411–1420PubMedCrossRef
15.
Park BG, Yoo CI, Kim HT, Kwon CH, Kim YK (2005) Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells. Toxicology 215:115–125PubMedCrossRef
16.
Ramachandiran S, Huang Q, Dong J, Lau SS, Monks TJ (2002) Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem Res Toxicol 15:1635–1642PubMedCrossRef
17.
Schweizer M, Peterhans E (1999) Oxidative stress in cells infected with bovine viral diarrhoea virus: a crucial step in the induction of apoptosis. J Gen Virol 80(Pt 5):1147–1155PubMed
18.
Shaul YD, Seger R (2007) The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 1773:1213–1226PubMedCrossRef
19.
Tikoo K, Lau SS, Monks TJ (2001) Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells. Mol Pharmacol 60:394–402PubMed
20.
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326–1331PubMedCrossRef
21.
Yamane D, Nagai M, Ogawa Y, Tohya Y, Akashi H (2005) Enhancement of apoptosis via an extrinsic factor, TNF-alpha, in cells infected with cytopathic bovine viral diarrhea virus. Microbes Infect 7:1482–1491PubMedCrossRef
22.
Yamane D, Kato K, Tohya Y, Akashi H (2006) The double-stranded RNA-induced apoptosis pathway is involved in the cytopathogenicity of cytopathogenic Bovine viral diarrhea virus. J Gen Virol 87:2961–2970PubMedCrossRef
23.
Yamane D, Kato K, Tohya Y, Akashi H (2008) The relationship between the viral RNA level and upregulation of innate immunity in spleen of cattle persistently infected with bovine viral diarrhea virus. Vet Microbiol 129:69–79PubMedCrossRef
24.
Yamane D, Zahoor MA, Mohamed YM, Azab W, Kato K, Tohya Y, Akashi H (2009) Microarray analysis reveals distinct signaling pathways transcriptionally activated by infection with bovine viral diarrhea virus in different cell types. Virus Res 142:188–199PubMedCrossRef
25.
Yamane D, Zahoor MA, Mohamed YM, Azab W, Kato K, Tohya Y, Akashi H (2009) Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis. J Biol Chem 284:13648–13659PubMedCrossRef
26.
Zhuang S, Schnellmann RG (2006) A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther 319:991–997PubMedCrossRef
Metadata
Title
Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus
Authors
Daisuke Yamane
Muhammad Atif Zahoor
Yassir Mahgoub Mohamed
Walid Azab
Kentaro Kato
Yukinobu Tohya
Hiroomi Akashi
Publication date
01-09-2009
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 9/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-009-0453-2

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