Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Archives of Virology
Published in: Archives of Virology 5/2009

01-05-2009 | Original Article

Characterization of Powassan viruses from Far Eastern Russia

Authors: Galina N. Leonova, Ilia G. Kondratov, Vladimir A. Ternovoi, Elena V. Romanova, Elena V. Protopopova, Eugene V. Chausov, Elena V. Pavlenko, Elena I. Ryabchikova, Sergey I. Belikov, Valery B. Loktev

Published in: Archives of Virology | Issue 5/2009

Login to get access

Abstract

We report the isolation and detailed characterization of the novel strain, Partizansk/2006, of Powassan virus (POWV) from a human case of infection, which occurred in Primorsky krai, Russia, in 2006. Comparative complete genome sequence analysis of the Far Eastern strains Spassk-9 (1975), Nadezdinsk-1991 and Partizansk/2006 of POWV revealed that these strains are 99.8% similar to the LB strain, which was isolated in Canada in 1958. Phylogenetic analysis of 5′ UTR sequences of five other strains of POWV isolated from 1972 to 1986 in Primorsky krai produced similar results. Presumably, Far Eastern POWV has common putative ancestor with LB strain POWV from North America, and the time of divergence of these POWVs is relatively short. We conclude that POWV has become endemic in Far Eastern Russia.
Literature
1.
McLean DM, Donahue W (1959) Powassan virus: isolation of virus from a fatal case of encephalitis. Can Med Assoc J 80:708–711PubMed
2.
Kuno G, Artsob H, Karabatsos N, Tsuchiya KR, Chang GJJ (2001) Genomic sequencing of deer tick virus and phylogeny of Powassan-related viruses of North America. Am J Trop Med Hyg 65:671–676PubMed
3.
Mandl CW, Holzmann H, Kunz C, Heinz FX (1993) Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses. Virology 194:173–184PubMedCrossRef
4.
Telford SR, Armstrong P, Katavolos P, Foppa I, Olmeda Garcia AS, Wilson ML, Spielman A (1997) A new tick-borne encephalitis-like virus infecting New England deer ticks Ixodes dammini. Emerg Infect Dis 3:165–170PubMedCrossRef
5.
Ebel GD, Spielman A 3rd (2001) Phylogeny of North American Powassan virus. J Gen Virol 82:1657–1665PubMed
6.
Calisher CH, Karabatsos N, Dalrymple JM, Shope RE, Porterfield JS, Westaway EG, Brandt WE (1989) Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J Gen Virol 70(Pt1):37–43PubMedCrossRef
7.
Gholam BI, Puksa S, Provias JP (1999) Powassan encephalitis: a case report with neuropathology and literature review. Can Med Assoc J 161:1419–1422
8.
Ralph ED (1999) Powassan encephalitis. JAMC 161:1416–1417
9.
Centers for Disease Control, Prevention (2001) Outbreak of Powassan encephalitis—main and vermont, 1999–2001. MMWR 50:761–764
10.
L’vov DK, Leonova GN, Gromashevskiĭ VL, Belikova NP, Berezina LK (1974) Isolation of the Powassan virus from Haemaphysalis neumanni Dönitz, 1905 ticks in the Maritime Territory. Vopr Virusol (5):538–541 (Russian)
11.
Krugliak SP, Leonova GN (1989) The significance of Ixodes ticks in the southern Far East in the circulation of Powassan virus. Vopr Virusol 34(3):358–362 (Russian)PubMed
12.
Leonova GN, Isachkova LM, Baranov NI, Krugliak SP (1980) Role of Powassan virus in the etiological structure of tick-borne encephalitis in the Primorsky Krai. Vopr Virusol (2):173–176 (Russian)
13.
Leonova GN, Sorokina MN, Krugliak SP (1991) The clinico-epidemiological characteristics of Powassan encephalitis in the southern Soviet Far East. Zh Mikrobiol Epidemiol Immunobiol (3):35–39 (Russian)
14.
Hozinskay GA (1986) Study of ecology and virology aspects for mixed infection of Powassan and TBE viruses in ticks, animals and cell cultures. PhD thesis, Moscow
15.
Lvov DK, Butenko AM, Gromashevsky VL, Kovtunov AI, Prilipov AG, Kinney R, Aristova VA, Dzharkenov AF, Samokhvalov EI, Savage HM, Shchelkanov MY, Galkina IV, Deryabin PG, Gubler DJ, Kulikova LN, Alkhovsky SK, Moskvina TM, Zlobina LV, Sadykova GK, Shatalov AG, Lvov DN, Usachev VE, Voronina AG (2004) West Nile virus and other zoonotic viruses in Russia: examples of emerging-reemerging situations. Arch Virol Suppl (18):85–96
16.
Safronov PF, Netesov SV, Mikriukova TP, Blinov VM, Osipova EG, Kiseleva NN, Sandakhchiev LS (1991) Nucleotide sequence of genes and complete amino acid sequence of tick-borne encephalitis virus strain 205. Mol Gen Mikrobiol Virusol (4):23–29 (Russian)
17.
Cheshenko NV, Petrov VS, Protopopova EV, Netesov SV, Konovalova SN, Belavin PA, Loktev VB, Malygin EG (1997) Recombinant vaccinia virus expressing Japanese encephalitis virus protein E. Mol Gen Mikrobiol Virusol (3):24–27 (Russian)
18.
Protopopova EV, Khusainova AD, Konovalova SN, Loktev VB (1996) Preparation and study of properties of anti-idiotypic antibodies, carrying hemagglutinating paratopes of tick-borne encephalitis virus on their surface. Vopr Virusol 41(2):50–53 (Russian)PubMed
19.
Gaidamovich SIa, Loktev VB, Lavrova NA, Maksutov AZ, Melnikova EE, Pereboev AV, Protopopova EV, Razumov IA, Sveshnikova NA, Khusainova AD (1990) Monoclonal antibodies cross-reacting with the tick-borne encephalitis virus and with the Venezuelan equine encephalomyelitis virus. Vopr Virusol 35(3):221–225 (Russian)PubMed
20.
Razumov IA, Kazachinskaia EI, Ternovoi VA, Protopopova EV, Galkina IV, Gromashevskii VL, Prilipov AG, Kachko AV, Ivanova AV, L’vov DK, Loktev VB (2005) Neutralizing monoclonal antibodies against Russian strain of the West Nile virus. Viral Immunol 18:558–568PubMedCrossRef
21.
Kumar S, Tamura K, Nei M (1993) MEGA: molecular evolution genetic analysis ver.1.0. The Pennsylvania State University, University Park, PA 16802
22.
Felsenstein J (1993) PHYLIP (phylogeny inference package) version 3.5c. Department of Genetics, University of Washington, Seattle
23.
Strimmer K, von Haeseler A (1997) PUZZLE: maximum likelihood analysis for nucleotide, aminoacid, and two-state data, version 4.0. Zoologisches Institut, Universitaet Muenchen, Germany
24.
David-West TS, Labzoffsky NA, Hamvas JJ (1972) Morphogenesis of yellow fever virus in mouse brain. Arch Gesamte Virusforsch 36:372–379PubMedCrossRef
25.
Barth O (1992) Replication of dengue viruses in mosquito cell cultures—a model from ultrastructural observations. Mem Inst Oswaldo Cruz 87:565–574PubMedCrossRef
26.
Mackenzie JM, Jones MK, Westaway EG (1999) Markers for trans-golgi membranes and the intermediate compartment localize to induced membranes with distinct replication functions in flavivirus-infected cells. J Virol 73:9555–9567PubMed
27.
Mackenzie JM, Westaway EG (2001) Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectively. J Virol 75:10787–10799PubMedCrossRef
28.
Isachkova LM, Shestopalova NM, Frolova MP, Reingold VN (1979) Light and electron microscope study of the neurotropism of Powassan virus strain P-40. Acta Virol 23:40–44PubMed
29.
Li WH, Tanimura M, Sharp PM (1988) Rates and dates of divergence between AIDS virus nucleotide sequences. Mol Biol Evol 5:313–330PubMed
30.
Filomatori CV, Lodeiro MF, Alvarez DE, Samsa MM, Pietrasanta L, Gamarnik AV (2006) A 5′ RNA enement promotes dengue virus synthesis on a circular genome. Genes Dev 20:2238–2249PubMedCrossRef
31.
Yu L, Nomaguchi M, Padmanabhan R, Markoff L (2008) Specific requirements for elements of the 5′ and 3′ terminal regions in flavivirus RNA synthesis and viral replication. Virology 374:170–185PubMedCrossRef
32.
Alvarez DE, Filomatori CV, Gamarnik AV (2008) Functional analysis of dengue virus cyclization sequences located at the 5′ and 3′ UTRs. Virology 375:223–235PubMedCrossRef
33.
Gareth M, Rambaut JA, Pybus OG, Holmes EC (2002) Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis. J Mol Evol 54:156–165CrossRef
34.
Lanciotti RS, Ebel GD, Deubel V, Kerst AJ, Murri S, Meyer R, Bowen M, McKinney N, Morrill WE, Crabtree MB, Kramer LD, Roehrig JT (2002) Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East. Virology 298:96–105PubMedCrossRef
35.
Ternovoi VA, Protopopova EV, Surmach SG, Gazetdinov MV, Zolotykh SI, Shestopalov AM, Pavlenko EV, Leonova GN, Loktev VB (2006) Genotyping of the West Nile virus in birds in Far Eastern region of Russia in 2002–2004. Mol Gen Mikrobiol Virusol (4):30–35
36.
Suzuki Y (2007) Multiple transmissions of tick-borne encephalitis virus between Japan and Russia. Genes Genet Syst 82:187–195PubMedCrossRef
37.
Hanada K, Suzuki Y, Gojobori T (2004) A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes. Mol Biol Evol 21:1074–1080PubMedCrossRef
38.
Main AJ, Carey AB, Downs WG (1979) Powassan virus in Ixodes cookei and Mustelidae in New England. J Wildl Dis 15:585–591PubMed
39.
Kollars TM Jr, Oliver JH Jr (2003) Host associations and seasonal occurrence of Haemaphysalis leporispalustris, Ixodes brunneus, I. cookei, I. dentatus, and I. texanus (Acari: Ixodidae) in Southeastern Missouri. J Med Entomol 40:103–107PubMedCrossRef
40.
Khromykh AA, Meka H, Guyatt KJ, Westaway EG (2001) Essential role of cyclisation sequences in flavivirus RNA replication. J Virol 75:6719–6728PubMedCrossRef
41.
Zuker M (2003) Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31:3406–3415PubMedCrossRef
42.
Mathews DH, Sabina J, Zuker M, Turner DH (1999) Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol 288:911–940PubMedCrossRef
Metadata
Title
Characterization of Powassan viruses from Far Eastern Russia
Authors
Galina N. Leonova
Ilia G. Kondratov
Vladimir A. Ternovoi
Elena V. Romanova
Elena V. Protopopova
Eugene V. Chausov
Elena V. Pavlenko
Elena I. Ryabchikova
Sergey I. Belikov
Valery B. Loktev
Publication date
01-05-2009
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 5/2009
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-009-0376-y

Other articles of this Issue 5/2009

Archives of Virology 5/2009 Go to the issue

Original Article

Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain

Annotated Sequence Record

Sequences of polycythemia-type Friend spleen focus-forming virus in clone-745-derived mouse erythroleukemia cells

Original Article

Characterization of monoclonal antibodies against the nonstructural 5A protein of hepatitis C virus

Original Article

Cloning of the genome of equine herpesvirus 4 strain TH20p as an infectious bacterial artificial chromosome

Original Article

Molecular, serological and biological variation among chickpea chlorotic stunt virus isolates from five countries of North Africa and West Asia

Original Article

Full genomic analysis of a human group A rotavirus G9P[6] strain from Eastern India provides evidence for porcine-to-human interspecies transmission
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits